What is pathophysiology of Colon cancer?

['Harim dispela pes']

Wanem samting i mekim na man i kisim sik kensa bilong bel?

Ol i tok dispela sik i save kamap taim ol samting i stap insait long bel i wok long go bikpela.

Dispela sik i save kamap long ol rop bilong bel.

Pastaim em i wanpela liklik buk i kamap long skin, na bihain em inap kamap kensa.

Ol samting i mekim na man i kisim sik kensa bilong bel i olsem: Ol jin i senis, sua, na ol samting i stap long ples.

Ol jin i save senis senis insait long DNA bilong ol sel bilong bel, na dispela i mekim na ol sel i no gro na bruk hariap.

Ol dispela senis inap kamap long rot bilong ol jin i stap long skin bilong man o long rot bilong ol jin i stap long skin bilong animal, na ol inap mekim sampela samting long ol jin i save helpim ol sel long kamap bikpela, o brukim ol sel, o stretim ol sel.

Ol i tok, ol i no save long risen na ol man i kisim dispela sik.

Taim skin i wok long go sua oltaim, dispela inap mekim na ol marasin i kamap long skin na dispela i kirapim ol sel long gro na bruk, na dispela inap kamapim sik kensa.

Ol samting i save kamap long ol samting yumi kaikai, na ol samting yumi mekim long i stap bilong yumi, na ol marasin samting yumi kisim, ol tu inap mekim na man i kisim sik kensa bilong bel.

Olsem: Sapos man i kaikai planti mit na abus ol i bin kukim, dispela inap mekim na man i kisim sik kensa bilong bel.

Sampela samting moa, olsem patpela skin, smok, na no eksasais, ol tu inap mekim na man i kisim sik.

Taim sik kensa bilong bel i kamap, em inap i go bikpela inap sampela haptaim, kirap long taim em i liklik yet na i go inap long taim em i bikpela pinis na i go long ol narapela hap bilong bodi.

Ol sel bilong kensa inap go insait long ol hap bilong bodi i stap klostu, na tu, ol inap go long ol hap i stap longwe olsem lewa o waitlewa.

Bilong stretim sik kensa bilong bel, ol i save katim man, givim kimoterapi, na givim sampela kain marasin olsem rediesen.

Ol dokta i save olsem taim man i kisim sik kensa long bel, dispela inap mekim na em i no inap kamap orait.

Ol dokta i save glasim gut bel bilong man na bai ol i ken save sapos em i gat sik kensa.

['Ol Tok Bilong Bipo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.

Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.

Chen JK, Yaffe MB: Atlas Drugged. Cell. 2019, 177 (4): 803-805.

Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.

Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.

Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.

Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.

['Toksave: sik']

['Dispela Web-sait i bilong skulim na givim save tasol long ol man, na i no bilong givim tok bilong helpim ol sikman o helpim ol narapela long sait bilong helt.']

['Ol i no ken yusim ol dispela tok bilong helpim ol long save long sik bilong ol, na ol man i laik kisim helpim long ol samting bilong helt, ol i mas toktok wantaim wanpela dokta.']

['Tingim, ol kompiuta i save yusim ol kompiuta long kamapim ol bekim bilong ol askim, tasol ol i no save kolim stret ol namba, olsem namba bilong ol man i gat wanpela sik.']

['Oltaim yu mas kisim tingting bilong dokta o narapela lain i gat save long helpim yu long sait bilong helt sapos yu gat sik. No ken sakim tok bilong dokta o wet long kisim tingting bilong dokta, long wanem, yu ritim sampela tok long dispela Web-sait. Sapos yu ting yu gat sik, ringim 911 o go long haus sik i stap klostu.']

['Toksave: raits bilong man i bosim']

['Digital Millennium Copyright Act bilong 1998, 17 U.S.C. § 512 (the DMCA) i tok ol papa bilong ol samting i gat rait long wokim ol samting, sapos ol i ting ol samting i stap long Intenet i brukim ol lo bilong ol long Amerika.']

['Sapos yu bilip olsem sampela samting i stap long dispela Web-sait o ol sevis bilong mipela i brukim lo bilong kopirait bilong yu, yu (o agent bilong yu) inap salim toksave long mipela na askim mipela long rausim o pasim rot bilong yu long kisim dispela samting.']

['Ol i mas salim ol toksave long rot bilong e-mail (lukim hap "Kontek" bilong lukim e-mail atres). ']

['Lo bilong DMCA i tok olsem toksave bilong yu long ol man i bin brukim lo bilong kopirait i mas i gat ol dispela tok: (1) stori long ol samting i gat kopirait long en, em ol man i tok ol i bin brukim; (2) stori long ol samting i gat kopirait na ol tok bilong helpim mipela long painim ol dispela samting; (3) ol tok bilong yu bilong salim pas long mipela, olsem atres, telefon namba, na e-meil atres; (4) tok yu bin mekim olsem yu bilip tru olsem man i gat kopirait o agent bilong em i no orait long ol samting i stap long dispela websait.']

['(5) Yu mas raitim wanpela pepa na putim han bilong yu bilong tokaut olsem ol tok bilong dispela pepa i stret na yu gat namba long mekim ol samting bilong lukautim ol rait bilong man i bin wokim ol samting.']

['Na (6) wanpela sain o sain bilong man i gat rait long wokim dispela samting o bilong wanpela man i gat namba long mekim wok bilong dispela man.']

['Sapos yu no raitim olgeta dispela tok, dispela inap mekim na ol i no stretim kwik komplen bilong yu.']

['Kontektim']

['Plis salim e-mail long mipela sapos yu gat sampela askim o tingting.']

What is pathophysiology of colon cancer?

The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.

Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.

It typically starts as a growth called a polyp, which can develop into cancer over time.

The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.

Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.

Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.

Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.

Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.

A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.

Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.

Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.

The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.

Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.

Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.

Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.

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