Pathophysiology ya bolwetse jwa sukiri e kaya go ithuta ka ga dithulaganyo tse di sa rulaganang tsa mmele tse di bakang bolwetse jwa sukiri.
Bolwetse jwa sukiri ke setlhopha sa malwetse a a amanang le go sila dijo a a bakwang ke selekanyo se se kwa godimo sa sukiri (glucose) mo mading a motho se se bakwang ke go sa direng sentle ga insulin kgotsa go sa direng sentle ga insulin kgotsa ka bobedi jwa tsone.
Pathophysiology ya bolwetse jwa sukiri e akaretsa go dirisana mmogo ga dijini, tikologo le tsela ya botshelo tse di dirang gore bolwetse jono bo nne teng.
Mo bolwetseng jwa sukiri jwa type 1, pathophysiology e akaretsa go senngwa ga disele tsa beta tse di ntshang insulin mo pancreas, mo go felelang ka gore go se ka ga ntshiwa insulin e e lekaneng.
Seno se dira gore selekanyo sa sukiri mo mading se se ka sa laolwa sentle, mme seo se dira gore motho a nne le sukiri e ntsi mo mading.
Mo bathong ba ba tshwerweng ke bolwetse jwa sukiri jwa type 2, pathophysiology ya jone e raraane thata mme e akaretsa go sa kgone go tsibogela insulin le go sa kgone go ntsha insulin sentle.
Insulin resistance e nna gone fa disele tsa mmele di sa tsibogele insulin sentle, mme seo se dira gore di se ka tsa kgona go dirisa glucose sentle go bona maatla.
Seno se dira gore lebete le ntshe insulin e ntsi gore le kgone go lwantsha bolwetse jono, mme fa nako e ntse e ya, lebete le ka nna la se ka la kgona go dira insulin e ntsi e e tlhokegang, mme seo se bo se dira gore insulin e se ka ya tlhola e ntshiwa.
Bolwetse jwa sukiri jwa boimana, jo bo nnang gone ka nako ya fa mosadi a imile, bo bakwa ke diphetogo tsa dihoromone tse di dirang gore mmele o se ka wa tlhola o kgona go tsibogela insulin.
Placenta e tlhagisa dihoromone tse di ka thibelang insulin go dira, mme seo se bo se dira gore selekanyo sa sukiri mo mading se tlhatloge.
Pathophysiology ya bolwetse jwa sukiri gape e akaretsa go nna le mathata, a a jaaka go senyega ga ditshika tsa madi, ditshika le dirwe, tse di ka bakang mathata a a masisi a botsogo a a jaaka bolwetse jwa pelo, seterouku, bolwetse jwa diphilo le go latlhegelwa ke pono.
Go tlhaloganya pathophysiology ya bolwetse jwa sukiri go botlhokwa thata gore go nne le mekgwa e e molemo ya go bo alafa le go bo thibela.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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