What is pathophysiology of Heart attack?

['Yingisela tluka leri']

Xana vuvabyi bya mbilu byi vangiwa hi yini?

Vuvabyi bya mbilu lebyi vuriwaka myocardial infarction byi katsa ku kavanyetiwa ka ngati leyi yaka eka xiphemu xa nsiha wa mbilu, leswi vangaka ku fa ka tisele ta mbilu.

Leswi swi tala ku vangiwa hi ku pfaleka ka nsiha wa mbilu hi ku va ku ri ni ngati leyi nga pfaleka, leyi hakanyingi yi vangiwaka hi vuvabyi bya ku tiya ka misiha ya mbilu, ku nga vuvabyi lebyi endlaka leswaku ku va ni swirhumbana emarhumbyini.

Plaque yi vumbiwa hi kholesteroli, mafurha, thyaka ra tisele, khalisiyamu ni fibrin.

Loko plaque yi pandzeka, yi nga endla leswaku ku vumbeka ngati leyi nga ta pfalela nsiha kutani yi sivela ngati leyi nga ni okisijini leswaku yi nga yi eka nsiha wa mbilu.

Ku kayivela ka okisijini loku ku endla leswaku tisele ta nsiha wa mbilu ti fa, leswi vangaka vuvabyi bya mbilu.

Mpimo wa ku vaviseka ka kona wu titshege hi mpimo wa ndhawu leyi pomperiwaka ngati eka yona hi nsiha lowu pfalekeke ni nkarhi lowu hundzeke ku sukela loko munhu a hlaseriwe hi vuvabyi lebyi ku fikela loko a kuma vutshunguri.

Swikombiso swa vuvabyi bya mbilu swi nga katsa ku vava kumbe ku nga titwi kahle exifuveni, ku heleriwa hi moya, ku hlamba timbilu, ku titivala ni ku vava emavokweni, enhan'wini, enhlaneni kumbe enhlaneni.

Hakanyingi vutshunguri bya vuvabyi bya mbilu byi katsa ku endla leswaku ngati yi tlhelela eka nsiha wa mbilu hi ku hatlisa hilaha swi nga kotekaka hakona, hi ku tirhisa mirhi kumbe hi ku tirhisa endlelo ro fana ni ku endla leswaku misiha ya mbilu yi nga ha tirhi kahle kumbe ku endla vuhandzuri byo susa misiha ya mbilu.

I swa nkoka ku xiya leswaku vuvabyi bya mbilu byi rharhanganile naswona byi katsa swilo swo tala, ku katsa ni switekela, mahanyelo ni mbango.

Swilo leswi nga endlaka leswaku munhu a khomiwa hi vuvabyi bya mbilu i ku tlakuka ka nsusumeto wa ngati, ku va ni kholesteroli yo tala, ku dzaha, vuvabyi bya chukele, ku nyuhela, ku nga endli vutiolori ni ku va ni vuvabyi bya mbilu endyangwini.

Ku lawula swilo leswi swi nga ha hunguta khombo ra ku khomiwa hi vuvabyi bya mbilu.

['Tinhlamuselo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Scott J: Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004, 14 (3): 271-9.

Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .

Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.

LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.

Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.

Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.

['Xihlambanyo xa vutihlamuleri: swa vutshunguri']

['Website leyi yi endleriwe ku dyondzisa ni ku nyika rungula ntsena naswona a yi nyiki switsundzuxo swa vutshunguri kumbe mintirho ya vativi va swa vutshunguri.']

['Rungula leri nyikeriweke a ri fanelanga ri tirhisiwa ku kambela kumbe ku tshungula xiphiqo xa rihanyo kumbe vuvabyi, naswona lava lavaka xitsundzuxo xa vutshunguri va fanele va vonana ni dokodela la nga ni mpfumelelo.']

['Xiya leswaku ndlela leyi ti-neural net ti hlamulaka swivutiso ha yona a yi pakanisi ngopfu loko ku vulavuriwa hi tinomboro, to tanihi nhlayo ya vanhu lava khomiweke hi vuvabyi byo karhi.']

["Minkarhi hinkwayo kombela xitsundzuxo eka dokodela wa wena kumbe eka muongori la fanelekaka malunghana ni xiyimo xa rihanyo ra wena. U nga tshuki u honisa xitsundzuxo xa dokodela kumbe u hlwela ku xi lava hikwalaho ka leswi u swi hlayeke eka website leyi. Loko u ehleketa leswaku u le xiyin'weni xa xihatla xa rihanyo, bela riqingho eka 911 kumbe u ya ekamareni ra xihatla leri nga ekusuhi na wena hi ku hatlisa. A ku na vuxaka bya dokodela ni muvabyi lebyi tumbuluxiweke hi website leyi kumbe ku tirhisiwa ka yona. BioMedLib kumbe vatirhi va yona, kumbe un'wana ni un'wana la hoxaka xandla eka website leyi, a nga endli switiyisekiso, leswi nga erivaleni kumbe leswi nga erivaleni, malunghana ni rungula leri nga laha kumbe ku tirhisiwa ka rona."]

['Ku ala ku byarha vutihlamuleri: mfanelo yo tsala']

['Nawu wa Digital Millennium Copyright Act wa 1998, 17 U.S.C. § 512 (DMCA) wu nyika tindlela ta ku tihlanganisa na vini va timfanelo ta vuhleri lava va tshembaka leswaku swilo leswi humelelaka eka Internet swi tlula timfanelo ta vona ehansi ka nawu wa vuhleri wa U.S.']

['Loko u tshemba leswaku rungula kumbe swilo leswi kumekaka eka website ya hina kumbe eka mintirho ya hina swi tlula mfanelo ya wena yo endla swilo, wena (kumbe muyimeri wa wena) u nga hi rhumela xitiviso u kombela leswaku rungula kumbe swilo leswi swi susiwa kumbe swi siveriwa.']

['Switiviso swi fanele ku rhumeriwa hi ku tsala hi imeyili (languta eka xiyenge xa "Vuxaka" eka adirese ya imeyili).']

["DMCA yi lava leswaku xitiviso xa wena xa ku tlula nawu wa mfanelo ya ku tsala xi katsa mahungu lawa landzelaka: (1) nhlamuselo ya ntirho lowu nga na mfanelo ya ku tsala lowu ku vuriwaka leswaku wu tluriwile; (2) nhlamuselo ya leswi ku vuriwaka leswaku swi tlula nawu wa ku tsala ni mahungu lama ringaneke ku hi pfumelela ku kuma leswi nga endzeni; (3) mahungu ya ku tihlanganisa na wena, ku katsa ni adirese ya wena, nomboro ya riqingho na adirese ya imeyili; (4) xitiviso xa wena xa leswaku u ni ripfumelo ra leswaku leswi nga endzeni hi ndlela leyi ku vilelaka ha yona a swi pfumeleriwanga hi n'wini wa mfanelo ya ku tsala, kumbe muyimeri wa yena, kumbe hi ku tirha ka nawu wihi na wihi; "]

['(5) xitiyisiso xa wena, lexi sayiniweke ehansi ka nxupulo wa ku hemba, xa leswaku mahungu lama nga eka xitiviso i ntiyiso ni leswaku u na matimba yo tirhisa timfanelo ta vuqambi leti ku vuriwaka leswaku ti tluriwile;']

["na (6) ku sayina ka xiviri kumbe ka elektroniki ka n'wini wa mfanelo ya vuqambi kumbe munhu la pfumeleriweke ku endla hi vito ra n'wini wa mfanelo ya vuqambi. "]

['Loko u nga nghenisi vuxokoxoko hinkwabyo lebyi nga laha henhla swi nga endla leswaku ku tirhana ni xivilelo xa wena swi hlwela.']

['Ku Tihlanganisa']

['Hi kombela u hi rhumela imeyili hi xivutiso/xiringanyeto xihi na xihi.']

What is pathophysiology of heart attack?

The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.

This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.

The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.

When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.

This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.

The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.

Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.

Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.

It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.

Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.

Managing these risk factors can help reduce the likelihood of experiencing a heart attack.

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