What is pathophysiology of Prostate cancer?

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Che cos'è a fisiopatologia del cancro ała prostata?

Ła patofisiologia del cancro de prostata ła se riferise ai mecanismi e ai processi che porta al sviłupo e ała progression deła małatia.

El cancro deła prostata xe un tumore maligno che vien fora dałe cellule deła prostata, che xe un organo picenin a forma de noxe che se cata soto ała vescica nei omeni.

Ła prostata ła produxe fluido seminale, che el nutre e el trasporta el sperma.

Ła causa esata del cancro ała prostata no ła xe conpletamente capìa, ma se sa che diversi fatori i aumenta el riscio de sviłupar ła małatia.

Questi include età, storia familiare, razza e serte mutassioni genetiche.

El cancro deła prostata xe pì comun nei omeni pì veci, co ła majoransa dei casi che se verifica nei omeni de pì de 65 anni.

Inoltre, i òmeni co na storia familiare de cancro ała prostata i xe a riscio aumentà, come i òmeni afroamericani e i òmeni de origine caraibica.

Ła patofisiologia del cancro deła prostata ła coinvolge ła crésita e divixion incontrolà dełe sèłułe drento deła prostata.

Questo pol suceder a causa de mutassiòn genetiche che porta ała sovraespression de serti fatori de cresita o ała inatività dei geni sopressori de tumori.

Ste mutassiòn pol portar a na cressita non regołada dełe cellule, portando ała formasión de un tumore.

Co el tumore crese, el pol invadar tessudi e organi visini, come vescica, retto e linfonodi visini.

In serti casi, łe celule cancerose łe se pol stacar dal tumore primario e sparpagnarse in altre parti del corpo atraverso el sangue o el sistema linfàtico, un processo conosùo come metastasi.

Na volta che el cancro se ga difondesto, pol essar pì difisiłe curarlo.

El cancro deła prostata pol anca esar influensà da fatori ormonali, in particołar da l'ormone androgeno testosterone.

El testosterone pol stimołar a cressita dełe cellule del cancro deła prostata e tanti trati pa'l cancro deła prostata i mira a ridur i livełi de sto ormone o blocar i so efeti.

In sintesi, a fisiopatologia del cancro de prostata coinvolge a cressita e a division incontrolà dełe cellule drento ała prostata, che pol esar influensà da fatori genetici, ormonali e ambientałi.

Capìr i mecanismi fondamentałi dea malatia xe fondamentałe pa sviłupar cure efficaci e migliorar i risultati pa i pasienti col cancro dea prostata.

['Riferimenti']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.

Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.

Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.

Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.

Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.

Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.

Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.

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What is pathophysiology of prostate cancer?

The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.

Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.

The prostate gland produces seminal fluid, which nourishes and transports sperm.

The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.

These include age, family history, race, and certain genetic mutations.

Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.

Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.

The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.

This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.

These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.

As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.

In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.

Once the cancer has spread, it can be more difficult to treat.

Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.

Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.

In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.

Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.

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