Pathophysiology ti akàn atẹgun tọka si awọn ayipada ninu awọn ilana physiological deede ati awọn ilana ti o waye ni idagbasoke ati ilọsiwaju ti akàn atẹgun.
Àrùn jẹjẹrẹ ẹdọfóró jẹ́ àìsàn tó díjú tó máa ń wáyé nígbà tí àwọn sẹ́ẹ̀lì tí kò bófin mu bá ń pọ̀ sí i, tí wọ́n sì ń pín sí i nínú ẹdọfóró.
Àwọn sẹ́ẹ̀lì wọ̀nyí lè di kòkòrò, kí wọ́n sì tàn dé àwọn apá mìíràn nínú ara, èyí sì lè fa onírúurú àmì àti ìṣòro.
Àwọn nǹkan bíi mélòó kan ló máa ń fa àrùn jẹjẹrẹ ẹ̀dọ̀fóró, títí kan àwọn àyípadà tó wà nínú àbùdá, àwọn nǹkan tó wà láyìíká, àti ọ̀nà tí wọ́n gbà ń gbé ìgbésí ayé.
Àwọn àyípadà àbùdá lè wáyé nínú DNA àwọn sẹ́ẹ̀lì ẹ̀dọ̀fóró, èyí tó máa ń mú kí sẹ́ẹ̀lì máa dàgbà tí kò sì lè pín sí i.
Wọ́n lè jogún àwọn àyípadà wọ̀nyí tàbí kí wọ́n gba wọ́n, wọ́n sì lè jẹ́ pé àwọn èròjà tó ń fa àrùn jẹjẹrẹ, irú bí èéfín sìgá, radon, asbestos, àti èéfín afẹ́fẹ́ ló ń fà á.
A lè pín àrùn jẹjẹrẹ ẹdọfóró sí oríṣi méjì: small cell lung cancer (SCLC) àti non-small cell lung cancer (NSCLC). NSCLC tún pín sí oríṣi mẹ́ta: adenocarcinoma, squamous cell carcinoma, àti large cell carcinoma.
Àwọn àrùn jẹjẹrẹ ẹdọfóró wọ̀nyí lè yàtọ̀ síra, nítorí pé wọ́n ní àwọn àbùdá tó yàtọ̀ síra, wọ́n sì máa ń fèsì sí ìtọ́jú lọ́nà tó yàtọ̀ síra.
Àìsàn jẹjẹrẹ ẹdọfóró tún ní í ṣe pẹ̀lú ìbánisọ̀rọ̀ tó wà láàárín àwọn sẹ́ẹ̀lì jẹjẹrẹ àti àwọn ẹ̀yà ara tó yí i ká, títí kan ètò ààbò.
Àwọn sẹ́ẹ̀lì jẹjẹrẹ lè yẹra fún ètò ààbò, èyí sì máa ń jẹ́ kí wọ́n máa dàgbà, kí wọ́n sì máa tàn kálẹ̀ láìsí ìdènà.
Pẹlupẹlu, microenvironment ti akàn le ṣe igbelaruge idagba akàn ati metastasis nipa pese agbegbe ti o ṣe atilẹyin fun awọn sẹẹli akàn.
Àkọsílẹ̀ nípa bí àrùn jẹjẹrẹ ẹ̀dọ̀fóró ṣe ń wáyé jẹ́ ohun tó díjú gan-an, àwọn olùṣèwádìí sì ń bá a lọ láti túbọ̀ lóye àwọn ohun tó ń fà á kí wọ́n lè ṣe ìtọ́jú tó gbéṣẹ́ sí i kí wọ́n sì mú kí àwọn aláìsàn láyọ̀ sí i.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
Ìyàsímímọ́: ìtọ́jú ìlera
Oju opo wẹẹbu yii ni a pese fun eto-ẹkọ ati awọn idi alaye nikan ati pe ko ṣe agbekalẹ pese imọran iṣoogun tabi awọn iṣẹ ọjọgbọn.
A ò gbọ́dọ̀ lo ìsọfúnni tó wà nínú ìwé náà láti ṣe àyẹ̀wò tàbí láti wo àìsàn tàbí àìsàn kan wò, àwọn tó bá sì ń wá ìmọ̀ràn nípa ìṣègùn fúnra wọn gbọ́dọ̀ bá dókítà tó ní ìwé àṣẹ sọ̀rọ̀.
Jọwọ ṣe akiyesi nẹtiwọọki neural ti o ṣe agbejade awọn idahun si awọn ibeere, jẹ pataki ti ko tọ nigbati o ba de si akoonu nọmba. Fun apẹẹrẹ, nọmba awọn eniyan ti a ṣe ayẹwo pẹlu aisan kan pato.
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Ìyàsímímọ́: ẹ̀tọ́ ọmọnìyàn
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Ti o ba gbagbọ ni igbagbọ to dara pe eyikeyi akoonu tabi ohun elo ti o wa ni asopọ pẹlu oju opo wẹẹbu wa tabi awọn iṣẹ ṣe ilokulo aṣẹ-aṣẹ rẹ, iwọ (tabi aṣoju rẹ) le firanṣẹ akiyesi kan si wa ti o beere pe a yọ akoonu tabi ohun elo naa kuro, tabi idilọwọ iraye si rẹ.
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(5) ìpolongo kan láti ọ̀dọ̀ rẹ, tí o fìdí rẹ̀ múlẹ̀ lábẹ́ ìjìyà ẹ̀rí èké, pé ìsọfúnni tó wà nínú ìkéde náà tọ̀nà àti pé o ní àṣẹ láti mú kí àwọn ẹ̀tọ́ ọmọnìyàn tí wọ́n sọ pé wọ́n ti rú ṣẹ ṣẹ;
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Ti o ko ba ṣafikun gbogbo alaye ti o wa loke le ja si idaduro ti ṣiṣe ẹdun rẹ.
Ìfọ̀rọ̀wérọ̀
Jọwọ fi imeeli ranṣẹ si wa pẹlu eyikeyi ibeere / imọran.
What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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