How is Prostate cancer diagnosed?

聽下呢個頁面

前列腺癌係點樣診斷出嘅呢?

前列腺癌係通過一系列測試同手術嚟診斷嘅,其中可能包括:

1. 手指直腸檢查 (DRE):醫生將一隻戴著手套,潤滑嘅手指插入直腸, 感覺前列腺有冇異常.

2. 前列腺特異抗原 (PSA) 測試:呢個係測量前列腺產生嘅蛋白質 PSA 水平嘅血液測試.

高PSA水平可能表明前列腺癌嘅存在.

3. 跨直肠超声波 (TRUS): 用一个小探头插入直肠,用声波拍摄前列腺的图像.

呢樣可以幫你發現前列腺嘅任何異常.

4. 活检: 取出一小部分前列腺组织,并在显微镜下检查是否有癌细胞.

呢個係唯一可以確定前列腺癌嘅診斷方法

5. 磁共振成像 (MRI): 前列腺嘅磁共振成像可以幫助發現任何異常,並引導生物檢查程序.

6. 基因檢查: 有啲醫生可能會用基因檢查嚟 決定癌症嘅侵襲性 同埋決定治療方法.

7. 骨頭掃描:可以進行骨頭掃描,以檢查癌症是否已擴散到骨頭.

8. 電腦掃描 (CT Scan): 可以用電腦掃描來檢查癌症是否已擴散到其他器官或組織.

值得注意嘅係,唔係所有 PSA 水平升高或者 DRE 結果異常嘅男性 都會患上前列腺癌,亦唔係所有前列腺癌都會引起 PSA 水平升高.

所以,要確定診斷,需要做生物檢查.

除此之外,如果一個人決定要做生物檢查, 佢會考慮到呢啲檢查嘅結果 同埋個人嘅風險因素同偏好.

參考資料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Saldova R, Fan Y, Fitzpatrick JM, Watson RW, Rudd PM: Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia. Glycobiology. 2011, 21 (2): 195-205.

Marenco J, Kasivisvanathan V, Emberton M: New standards in prostate biopsy. Arch Esp Urol. 2019, 72 (2): 142-149.

Moradi M, Mousavi P, Abolmaesumi P: Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review. Ultrasound Med Biol. 2007, 33 (7): 1010-28.

Cuperlovic-Culf M, Belacel N, Davey M, Ouellette RJ: Multi-gene biomarker panel for reference free prostate cancer diagnosis: determination and independent validation. Biomarkers. 2010, 15 (8): 693-706.

McGrath SE, Michael A, Morgan R, Pandha H: EN2: a novel prostate cancer biomarker. Biomark Med. 2013, 7 (6): 893-901.

An Y, Chang W, Wang W, Wu H, Pu K, Wu A, Qin Z, Tao Y, Yue Z, Wang P, Wang Z: A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn2+ in healthy versus cancerous cells. J Adv Res. 2020, 24 (): 363-370.

[Consensus of Chinese experts on the application of molecular imaging targeting prostate specific membrane antigen in prostate cancer patients]. Zhonghua Wai Ke Za Zhi. 2018, 56 (2): 91-94.

Zhong WD, He HC, Bi XC, Ou RB, Jiang SA, Liu LS: cDNA macroarray for analysis of gene expression profiles in prostate cancer. Chin Med J (Engl). 2006, 119 (7): 570-3.

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How is prostate cancer diagnosed?

Prostate cancer is diagnosed through a combination of tests and procedures, which may include:

1. Digital Rectal Exam (DRE): A doctor inserts a gloved, lubricated finger into the rectum to feel the prostate for any abnormalities.

2. Prostate-Specific Antigen (PSA) Test: This is a blood test that measures the level of PSA, a protein produced by the prostate gland.

Elevated PSA levels may indicate the presence of prostate cancer.

3. Transrectal Ultrasound (TRUS): A small probe is inserted into the rectum to create an image of the prostate using sound waves.

This can help identify any abnormalities in the prostate gland.

4. Biopsy: A small sample of prostate tissue is removed and examined under a microscope for the presence of cancer cells.

This is the only definitive way to diagnose prostate cancer.

5. Magnetic Resonance Imaging (MRI): An MRI scan of the prostate can help identify any abnormalities and guide the biopsy procedure.

6. Genomic Testing: Some doctors may use genomic tests to help determine the aggressiveness of the cancer and guide treatment decisions.

7. Bone Scan: A bone scan may be performed to check if the cancer has spread to the bones.

8. Computed Tomography (CT) Scan: A CT scan may be used to check if the cancer has spread to other organs or tissues.

It is important to note that not all men with elevated PSA levels or abnormal DRE results will have prostate cancer, and not all prostate cancers will cause elevated PSA levels.

Therefore, a biopsy is necessary to confirm the diagnosis.

Additionally, the decision to undergo a biopsy is made after considering the results of these tests and the individual's risk factors and preferences.

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