What causes Colon cancer?

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乜嘢會導致結腸癌?

大腸癌,亦稱為大腸直腸癌, 由大腸或直腸中異常細胞嘅無控制生長引起.

大腸癌嘅確切原因未知,但有幾種因素可以增加患上呢個病嘅風險.

其中包括:

1. 年齡: 大腸癌嘅風險隨著年齡增加,大多數病例喺 50 歲以上嘅人身上發生.

2. 家庭史: 腸癌或多胞體嘅個人或家庭史會增加患上呢個病嘅風險.

3. 遺傳性症候群:某些遺傳性基因症候群,例如家族性狀多元化 (FAP) 同遺傳性非多元化結腸癌 (HNPCC),可以增加結腸癌嘅風險.

4. 生活方式嘅因素: 食紅肉同加工肉,肥胖,吸煙同過度飲酒 都可以增加結腸癌嘅風險.

5. 炎症性腸道疾病:長期炎症性腸道疾病,例如性大腸炎同克羅恩病,可以增加結腸癌嘅風險.

6. 2 型糖尿病: 2 型糖尿病患者患結腸癌嘅風險增加.

7.放射線治療:對其他腹部癌症嘅放射線治療可以增加結腸癌嘅風險.

8. 種族:非裔美國人比其他種族更容易患上結腸癌.

值得注意嘅係,有一個或多個風險因素並唔一定意味著一個人會患上結腸癌, 而有啲患上結腸癌嘅人可能冇任何已知嘅風險因素.

定期嘅檢查同早期發現 可以幫助防止結腸癌,或者喺最容易治療嘅早期發現

參考資料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

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What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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