What causes Colon cancer?

Yini ebangela umdlavuza wamathumbu?

Umdlavuza wamathumbu, owaziwa nangokuthi umdlavuza wamathumbu, ubangelwa ukukhula okungalawuleki kwamangqamuzana angavamile emathunjini noma emathunjini.

Imbangela eqondile yomdlavuza wamathumbu ayaziwa, kodwa kunezinto eziningana ezingandisa ingozi yokuba nalesi sifo.

Lezi zihlanganisa:

1. Ubudala: Ingozi yomdlavuza wamathumbu iyanda lapho umuntu esemdala, futhi iningi lamacala livela kubantu abaneminyaka engaphezu kwamashumi amahlanu.

Umlando womkhaya: Umlando womuntu siqu noma womkhaya womdlavuza wamathumbu noma ama-polyps wandisa ingozi yokuba nalesi sifo.

3. Izifo ezizuzwayo: Izifo ezithile ezizuzwayo zezakhi zofuzo, njenge-familial adenomatous polyposis (FAP) nomdlavuza we-colorectal ongenayo i-polyposis (HNPCC), zingandisa ingozi yomdlavuza wamathumbu.

4. Izinto eziphathelene nendlela yokuphila: Ukudla inyama ebomvu neyenziwe ngomshini, ukukhuluphala, ukubhema, nokuphuza ngokweqile kungandisa ingozi yomdlavuza wamathumbu.

5. Isifo sokuvuvukala kwamathumbu: Izifo zokuvuvukala kwamathumbu zesikhathi eside, njenge-ulcerative colitis nesifo sikaCrohn, zingandisa ingozi yomdlavuza wamathumbu.

Isifo sikashukela sohlobo 2: Abantu abanesifo sikashukela sohlobo 2 basengozini enkulu yokuthola umdlavuza wamathumbu.

7. Ukwelashwa ngemisebe: Ukwelashwa ngemisebe kwezinye izinhlobo zomdlavuza wesisu kungandisa ingozi yomdlavuza wamathumbu.

8. Uhlanga: Abantu base-Afrika baseMelika basengozini enkulu yokuthola umdlavuza wamathumbu kunabanye abantu.

Kubalulekile ukuphawula ukuthi ukuba nesici esisodwa noma eziningi zalezi zici zobungozi akusho ukuthi umuntu uyoba nomdlavuza wamathumbu, futhi abanye abantu ababa nomdlavuza wamathumbu bangase bangabi nazo izici zobungozi ezaziwayo.

Ukuhlolwa njalo nokutholakala kusenesikhathi kungasiza ekuvimbeleni umdlavuza wamathumbu noma ukuwuthola kusenesikhathi lapho ungelapheka kakhulu.

Izikhombo

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

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Imininingwane enikeziwe akufanele isetshenziselwe ukuxilonga noma ukwelapha inkinga noma isifo, futhi labo abafuna iseluleko somuntu siqu sezokwelapha kufanele babonane nodokotela onelayisense.

Sicela uqaphele ukuthi inethiwekhi ye-neural ekhiqiza izimpendulo zemibuzo, ayinembile ngokukhethekile uma kuziwa kokuqukethwe kwezinombolo. Ngokwesibonelo, inani labantu abanesifo esithile.

Ngaso sonke isikhathi funa iseluleko sikadokotela wakho noma omunye umhlinzeki wezempilo ofanelekayo mayelana nesimo sezokwelapha. Ungalokothi ungayinaki iseluleko sezokwelapha sobungcweti noma ubambezele ukusifuna ngenxa yento oyifundile kule webhusayithi. Uma ucabanga ukuthi ungase ube nesimo esiphuthumayo sezokwelapha, shayela i-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha. Ayikho ubudlelwano bokuthi udokotela-isiguli obakhiwe yile webhusayithi noma ukusetshenziswa kwayo. I-BioMedLib noma abasebenzi bayo, noma noma yimuphi umnikeli wale webhusayithi, akenzi noma yimiphi imibono, ecacile noma ecacile, mayelana nolwazi olunikezwe lapha noma ukusetshenziswa kwayo.

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Othintana naye

Sicela usithumelele i-imeyili nganoma yimiphi imibuzo / iziphakamiso.

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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