How to treat Prostate cancer?

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Hoe om prostaatkanker te behandel?

Daar is verskeie behandelingsopsies beskikbaar vir prostaatkanker, afhangende van die stadium en aggressiviteit van die kanker, sowel as die pasiënt se algemene gesondheid en persoonlike voorkeure.

Sommige algemene behandelings sluit in:

1. Aktiewe toesig: Hierdie benadering behels om die kanker noukeurig te monitor deur middel van gereelde ondersoeke en toetse, eerder as om onmiddellik met behandeling te begin.

Dit kan geskik wees vir mans met lae-risiko prostaatkanker.

2. Chirurgie: 'n Prostatektomie is 'n chirurgiese prosedure om die prostaatklier te verwyder.

Dit kan gedoen word deur middel van oop chirurgie of laparoskopies (met behulp van klein insnydings en gespesialiseerde gereedskap).

3. Bestralingsterapie: Hierdie behandeling gebruik hoog-energie bestraling om kanker selle dood te maak.

Dit kan ekstern (van 'n masjien buite die liggaam) of intern (deur implantate wat naby die gewas geplaas word) afgelewer word.

4. Hormonale terapie: Hierdie behandeling verminder die vlakke van manlike hormone (androgene) in die liggaam, wat die groei van prostaatkanker kan vertraag of stop.

Dit kan alleen of in kombinasie met ander behandelings gebruik word.

5. Chemoterapie: Hierdie behandeling gebruik dwelms om kankerselle dood te maak.

Dit kan gebruik word vir gevorderde prostaatkanker wat na ander dele van die liggaam versprei het.

6. Immunoterapie: Hierdie behandeling help die immuunstelsel om kanker te beveg.

Dit kan gebruik word vir gevorderde prostaatkanker wat nie op ander behandelings gereageer het nie.

7. Gerigte terapie: Hierdie behandeling is gerig op spesifieke gene of proteïene wat kanker selle help om te groei en te oorleef.

Dit kan gebruik word vir gevorderde prostaatkanker wat nie op ander behandelings gereageer het nie.

8. Kryoterapie: Hierdie behandeling gebruik uiterste koue om kanker selle te vries en dood te maak.

Dit kan gebruik word vir vroeë stadium prostaatkanker of vir kanker wat na ander behandelings teruggekeer het.

9. Hoë-intensiteit gefokusde ultraklank (HIFU): Hierdie behandeling gebruik hoëfrekwensie klankgolwe om kanker selle te verhit en te vernietig.

Dit kan gebruik word vir vroeë stadium prostaatkanker of vir kanker wat na ander behandelings teruggekeer het.

10. Waaksaam wag: Hierdie benadering behels dat die kanker noukeurig gemonitor word met gereelde ondersoeke en toetse, maar dat behandeling nie begin word tensy simptome verskyn of verander nie.

Dit kan geskik wees vir ouer mans met stadig groeiende prostaatkanker en ander ernstige gesondheidstoestande.

Dit is belangrik om alle behandelingsopsies met 'n gesondheidsorgspan te bespreek om die beste aksie vir elke individuele geval te bepaal.

Verwysings

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Wang Y, Chen J, Wu Z, Ding W, Gao S, Gao Y, Xu C: Mechanisms of enzalutamide resistance in castration-resistant prostate cancer and therapeutic strategies to overcome it. Br J Pharmacol. 2021, 178 (2): 239-261.

Talkar SS, Patravale VB: Gene Therapy for Prostate Cancer: A Review. Endocr Metab Immune Disord Drug Targets. 2021, 21 (3): 385-396.

Šamija I, Fröbe A: CHALLENGES IN MANIPULATING IMMUNE SYSTEM TO TREAT PROSTATE CANCER. Acta Clin Croat. 2019, 58 (Suppl 2): 76-81.

Akaza H, Hinotsu S, Usami M, Ogawa O, Kagawa S, Kitamura T, Tsukamoto T, Naito S, Hirao Y, Murai M, Yamanaka H, Namiki M: The case for androgen deprivation as primary therapy for early stage disease: results from J-CaP and CaPSURE. J Urol. 2006, 176 (6 Pt 2): S47-9.

Abraham-Miranda J, Awasthi S, Yamoah K: Immunologic disparities in prostate cancer between American men of African and European descent. Crit Rev Oncol Hematol. 2021, 164 (): 103426.

de Vrij J, Willemsen RA, Lindholm L, Hoeben RC, Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G: Adenovirus-derived vectors for prostate cancer gene therapy. Hum Gene Ther. 2010, 21 (7): 795-805.

Lee E, Ha S, Logan SK: Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells. PLoS One. 2015, 10 (10): e0141589.

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How to treat prostate cancer?

There are several treatment options available for prostate cancer, depending on the stage and aggressiveness of the cancer, as well as the patient's overall health and personal preferences.

Some common treatments include:

1. Active surveillance: This approach involves closely monitoring the cancer with regular checkups and tests, rather than immediately starting treatment.

It may be suitable for men with low-risk prostate cancer.

2. Surgery: A prostatectomy is a surgical procedure to remove the prostate gland.

It can be done through open surgery or laparoscopically (using small incisions and specialized tools).

3. Radiation therapy: This treatment uses high-energy radiation to kill cancer cells.

It can be delivered externally (from a machine outside the body) or internally (through implants placed near the tumor).

4. Hormone therapy: This treatment reduces the levels of male hormones (androgens) in the body, which can slow or stop the growth of prostate cancer.

It can be used alone or in combination with other treatments.

5. Chemotherapy: This treatment uses drugs to kill cancer cells.

It may be used for advanced prostate cancer that has spread to other parts of the body.

6. Immunotherapy: This treatment helps the immune system fight cancer.

It may be used for advanced prostate cancer that has not responded to other treatments.

7. Targeted therapy: This treatment targets specific genes or proteins that help cancer cells grow and survive.

It may be used for advanced prostate cancer that has not responded to other treatments.

8. Cryotherapy: This treatment uses extreme cold to freeze and kill cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

9. High-intensity focused ultrasound (HIFU): This treatment uses high-frequency sound waves to heat and destroy cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

10. Watchful waiting: This approach involves closely monitoring the cancer with regular checkups and tests, but not starting treatment unless symptoms appear or change.

It may be suitable for older men with slow-growing prostate cancer and other serious health conditions.

It is important to discuss all treatment options with a healthcare team to determine the best course of action for each individual case.

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