Pathophysiology ya cancer ya colon yinalumbunuka yuma yize yakuneha yikola yacho.
Cikola ya colon, yize anavuluka nawa ngwo colorectal cancer, yili mutapu wa cancer yize yakuputuka mu colon hanji mu rectum, yize yili chihanda cha mala anene.
Pathophysiology ya cancer ya colon yili ni yuma yinji, ngwe kwalumuka cha genetic, yikola ni yuma ya ku mbunga.
Mutações genéticas mahasa kulingiwa ha DNA ya ma celula ja colon, ni kutwala ha kukola ni kulihandununa cha ma celula.
Mutação yacho mahasa kuyitambula kuli ana hanji kuli mutu mwene, nawa yakwata ku ma genes waze akwasa ha kukola cha célula, ni kulihandununa ni kulilulieka.
Uchiji ha malaji, uze wakuneha yikola ya malaji, nawa muuhasa kutohwesa yikola ya cancer.
Kufwika cha miaka yeswe chakukwasa ma celula hanga aikole ni kulihandununa, chino chakuneha yikola ya cancer.
Chakutalilaho, kulia yifwo yize yili ni yifwo ya kusuka ni ya kuyifumba, chakukwasa chinji yikola ya cancer.
Yuma yikwo ngwe, kupwa ni yifwi, kunwa makanya, ni kuhona kulinga yuma yize yakukolesa mujimba, muyihasa nawa kutohwesa yikola yacho.
Muze cancer ya colon muyiza, muyihasa kuya mu ma etape anji, kukatuka ku cancer yize yili ha mashimbu akehe, yize yakupwa wika ha colon, ni kuya ha mashimbu waze yikweta yikola yinji, muze cancer yakuna mu yihanda yikwo ya mujimba.
Maselusi a kansa mahasa kuputuka ni kulifumba mu mujimba, ni ku yalisa mu manyinga ni mu manyinga hanga ayize mu yihela yeka, ngwe mu jishi hanji mu fupa.
Uukiso wa cancer ya colon unatale ha kuhengula, ha kuchiza yitumbo ya cancer ni ya radiation, nikulita ni kuchiza ni kuze yili.
Kuhengwola kanawa musongo wacho chili chilemu chinji mumu musongo wacho kakuuchiza muze uli mu chipatulo chitangu.
Kuhengwola mashimbu eswe, ngwe kulinga colonoscopy, muchihasa kukwasa hanga unyingike kansa ha mashimbu akehe-akehe muze muchihasa kuyiwuka.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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