Pathophysiology ya cancer ya prostate yinalumbunuka yuma yize yakuneha yikola yacho.
Cikola cha kansa ya prostate yili yikola yize yakukwata atu waze ali ni kansa yacho.
Prostate gland yakukasa yikola ya seminal, yize yakukwasa ni kuyendesa ayo.
Chuma cheji kulingisanga musongo wa kansa kuchinyingike kanawa, alioze kuli yuma yinji yize yakuneha musongo wacho.
Chino chili ngwe miaka, usoko, vungu ni kwalumuka cha shinga.
Musongo wa prostate unji ku malunga waze ali ni miaka yinji, unji wa atu waze akuyiza ni kansa wacho kali waze ali ni miaka 65 ni kuhiana.
Nawa malunga waze asoko jo kakwete yikola yacho, kali mu ponde.
Musongo wa cancer ya prostate unatale ha kukola ni kulihandununa cha ma celula mu prostate gland.
Chino muchihasa kulingiwa ha mukunda wa kwalumuka cha shinga chize chakuneha kukola cha yuma yize yakukolesa hanji kukoka cha ma genes.
Chino muchihasa kulingisa maselusi kukola chakuhona kulita ni chize chinatela kupwa ni tumor.
Muze tumor yakula, muyihasa kuputuka kuyijiha yihanda yize yili hakamwihi, ngwe musongo wa chisuji, hanji haze hakutuhuka mujimo.
Ha mashimbu amwe, ma celula a cancer mahasa kuputuka ku tumor yitangu ni kuhanda ni kulianga mu yihanda yikwo ya mujimba ha kupalika cha manyinga hanji ha sistema ya lymphatic, chino kakuchinyingika ngwo metastasis.
Testosterone yakukwasa hanga ma celula a cancer a prostate akole chinji, nawa yikumba yinji yize akuzachisa hanga akuhwise kansa yacho yakukwasa hanga akeheseko hormone yacho hanji ahone kuyikoka.
Ha chino, uhashi wa cancer ya prostate unatale ha kukola ni kulihandununa cha ma celula mu prostate gland, chino muchihasa kupwa ni yikola ya mu citumbo, ya mu mijimba ni ya mu chifuchi.
Kunyingika kanawa yize yakuneha yikola yacho chili chilemu chinji hanga atu ahase kuchiza kanawa yikola yacho ni kuhwisa yikola yacho.
Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.
Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.
Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.
Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.
Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.
Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.
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['Shimbi ya DMCA yinambe ngwo, sango je ha yize akuhanjika ngwo yapinjisa shimbi ja akwa-kusoneka yili ni sango jacho: (1) kulumbununa mulimo uze uli ni shimbi ja akwa-kusoneka uze anazangamisa; (2) kulumbununa yikuma yize anazangamisa ni sango jize jinahase kutukwasa hanga tuwane yikuma yacho; (3) kulweza yoze mutuhasa kumuheta, ngwe adresi, numero ya telefone ni email; (4) maliji waze yena musolola ngwo, yuma yize anazangamisa kuyishi ni utayizo wa mwene wa shimbi ja akwa-kusoneka, hanji yoze akuzachisa, hanji ni shimbi jize anazangamisa; ']
['(5) Sango jize yena musoneka, ni shimbi jize makahana, ngwo sango jize jili ha mukanda jili ja umwenemwene nawa uli ni ulite wakukwasa hanga akwa-kusoneka afunge shimbi jize anakwambulula ngwo jinalitepulula;']
['nawa (6) chijimbikilo cha mwata wa shindakenyo ya ulite wa yuma hanji cha muthu yoze uli ni ulite wa kulinga yuma ha jina lia mwata wa shindakenyo ya yuma.']
The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.
Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.
The prostate gland produces seminal fluid, which nourishes and transports sperm.
The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.
These include age, family history, race, and certain genetic mutations.
Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.
Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.
The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.
This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.
These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.
As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.
In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.
Once the cancer has spread, it can be more difficult to treat.
Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.
Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.
In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.
Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.
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