Na mate ni uto e vakatokai na myocardial infarction, e vakavuna na kena sega ni drodro vinaka na dra ina dua na iwase ni uto, lai tini sara ena nodra mate na sela ni uto.
E dau yaco oqo ni sa sogota na sala ni dra na blood clot, e dau vakavuna na atherosclerosis, na kena dau tubu na uro ena sala ni dra.
Na plaque e tiko kina na cholesterol, uro, benu, calcium, kei na fibrin.
Ni kacabote na plaque, e rawa ni vakavuna me tubu na dra, e rawa ni sogota na sala ni dra qai tarova na kena drodro na dra e levu kina na oxygen ina uto.
Na lailai ni cagi e curu ina uto ena vakavuna na kena mate na sela ni uto, e rawa ni tini sara ena mateniuto.
Na levu ni mavoa ena vakatau ena levu ni vanua e tabonaki kina na sala ni dra kei na dede ni gauna e yaco kina na mate.
E rawa ni vakavuna na mateniuto na mosi ni sereda, cegu leka, lomalomaca, lialia, mosi na liga, domo, galegale, se daku.
Na veiqaravi ni mateniuto e okati kina na kena vakalesui totolo na dra ina uto, me vakayagataki na wainimate se na veiqaravi me vaka na angioplasty kei na stenting se na coronary artery bypass surgery.
E bibi me nanumi ni vereverea na mate ni uto qai okati kina e levu na ka, wili kina na ka e dewa mai na kawa, ivakarau ni bula, kei na veika e dau yaco ena noda itikotiko.
E rawa ni tauvi iko na mateniuto ke tubu na ivakarau ni nomu dra, tubu na cholesterol, vakatavako, matenisuka, levulevu sivia, sega ni vakaukauayago, qai tauvi iko e dua na mate ni uto ena nomu vuvale.
Na kena lewai vinaka na veika e rawa ni vakavuna na mateniuto ena rawa ni vakalailaitaka na kena rawa ni tauvi iko.
Scott J: Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004, 14 (3): 271-9.
Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .
Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.
LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.
Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.
Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.
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What is pathophysiology of heart attack?
The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.
This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.
The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.
When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.
This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.
The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.
Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.
Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.
It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.
Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.
Managing these risk factors can help reduce the likelihood of experiencing a heart attack.
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