What is pathophysiology of Prostate cancer?

['Ehendu ko kuatiarogue']

Mba'e fisiopatología oreko cáncer de próstata?

Carcinoma de próstata patofisiología oñe'ẽ hína umi mecanismo ha proceso subyacente ogueraháva mba'asy ñemongakuaa ha iñemboguatápe.

Káncer de próstata ningo hína peteĩ tumor maligno osẽva glándula prostática célula-kuéragui, ha'éva peteĩ órgano michĩ, nogal joguaha oĩva vejiga guýpe kuimba'épe.

Próstata ojapo fluido seminal, omongarúva ha ombohasa esperma.

Ndojeikuaaporãi mba'etépa ome'ẽ ñandéve cáncer de próstata, katu oĩ heta mba'e ojeikuaáva ombohetaveha ko mba'asy.

Ko'ãva apytépe oĩ ary, antecedente familiar, raza ha ambue mutación genética.

Cáncer de próstata ojehechave kuimba'e itujavéva apytépe, hetave umi káso oúva kuimba'e 65 ary ohasávape.

Avei, umi kuimba'e ifamilia oguerekóva cáncer de próstata oguereko hetave riesgo, upéicha avei umi afroamericano ha caribeño.

Carcinoma de próstata patofisiología-pe ojeroike hína célula-kuéra ñemboheta ha ñemboja'o ojejoko'ỹva glándula prostática ryepýpe.

Kóva ikatu oiko umi mutación genética rupive ombohapéva expresión excesiva ambue factor de crecimiento rehegua térã umi gen supresor tumoral inactivación.

Ko'ã mutación ikatu ombohape umi célula akãrapu'ãregua, ombohapéva tumor apo.

Okakuaave jave, ikatu oike umi tejido ha órgano oĩva ijykére rehe, taha'e vejiga, recto ha ganglios linfáticos oĩva ijykére.

Oĩ kásope, umi célula cancerígena ikatu ojei tumor primario-gui ha isarambi ambue tendápe ñande rete ryepýpe sangre rupive térã sistema linfático rupive, peteĩ proceso ojekuaáva metástasis-ramo.

Peteĩ jey cáncer ojeipysóramo, ikatu hasyve oñepohano haguã.

Umi factor hormonal ikatu avei opoko próstata rehe, ha'eve hína andrógeno rehegua hormona testosterona.

Testosterona ikatu omombarete umi célula oguerekóva cáncer de próstata ñemongakuaa, ha heta ñepohano ojejapóva kóva rehegua omboguejyve ko hormona térã ojoko efecto oguerekóva.

Ñambopahavo, fisiopatología cáncer de próstata rehegua oike akãrapu'ã ha célula ñemboja'o ojejoko'ỹva glándula prostática ryepýpe, ikatúva oguereko influencia factor genético, hormonal ha ambiental.

Jeikuaave mba'éichapa ko mba'asy oiko tekotevẽterei oñepohano porãve hag̃ua ha ojehupytyve hag̃ua mba'e porã umi hasýva cáncer de próstata-gui.

['Jehechapy']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.

Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.

Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.

Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.

Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.

Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.

Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.

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["Akóinte eheka ne pohãnohára térã ambue pohanohára ikatupyrýva ñe'ẽ peteĩ mba'asýpe. Ani araka'eve remboyke térã reha'arõ'ỹ rehekávo ñe'ẽ pohanohára ikatupyrýva ñe'ẽ remoñe'ẽre ko ñanduti rendápe. Reimo'ãramo ikatuha reikotevẽ peteĩ mba'e hasýva, ehenoikuaa 911 térã tereho pya'e tasyópe. Ko ñanduti renda térã ijeporu ndojapói mba'eveichagua pohanohára ha hasýva jokupyty. BioMedLib, imba'apohára térã oimeraẽ tapicha oipytyvõva ko ñanduti rendápe, nomboajéi mba'eve, he'íva térã he'iséva, marandu oĩva ko'ápe térã ijeporu."]

['Copyright: Copyright']

["Pe Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (DMCA) ome'ẽ recurso umi copyright járape ogueroviáva umi mba'e ojehechaukáva Internet-pe opokovaiha iderecho rehe EE.UU. léi jehaiporãmby rehegua rupive. "]

["Rogueroviáramo añetehápe oimeraẽ mba'e térã tembiporu ojepurukuaáva ore ñanduti renda térã tembipurupyahu rupive opyrũha ne derécho rehe, nde (térã ne rembijokuái) ikatu oremondo peteĩ ñemomarandu ojerurévo ojeipe'a hag̃ua upe mba'e térã tembiporu, térã ojejokopa hag̃ua ijeike. "]

['Umi ñemomarandu oñemog̃uahẽva\'erã kuatia rupive, correo electrónico rupive (ojehecháta "Contacto" pe).']

["DMCA ojerure ne ñemomarandu rehe ejaposégui mba'evai ejaposéva rehe toike ko'ã mba'e: (1) tembiapo ojejaposéva rehegua ha'éva mba'evai; (2) jehaipy ha mba'ekuaarã ome'ẽva oréve jehaipyre ha'éva mba'evai ha ome'ẽva oréve pa'ũ rojuhu hag̃ua; (3) ne ñanduti veve, ne rendaite, ne pumbyry papapy ha ne ñanduti veve; (4) ñe'ẽme'ẽ erekóva rejeroviaha pe mba'evai ejaposéva rehe ndojeruréiha mba'evai apohára, imaranduhára térã léi."]

["5. peteî declaración nde rejapóva, remoîva nde réra ha remoîva'erâha nde jurúpe, umi mba'e oîva ñemomarandúpe oîmbaha añetehápe ha rerekoha pokatu remoañete haguâ umi derecho oje'éva nde rehe ojepoko vaiha;"]

["ha (6) peteĩ firma física térã electrónica copyright jára rehegua térã peteĩ tapicha omoneĩva oporoñemomba'e hag̃ua copyright jára rérape. "]

["Ndoikéi ramo opaite ko'ã mba'e ikatu ombohape nde denuncia ñemboguata."]

['Ñemboheraguapy']

["Remba'eporanduséramo térã ereko hag̃ua ne remiandu ehai oréve."]

What is pathophysiology of prostate cancer?

The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.

Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.

The prostate gland produces seminal fluid, which nourishes and transports sperm.

The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.

These include age, family history, race, and certain genetic mutations.

Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.

Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.

The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.

This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.

These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.

As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.

In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.

Once the cancer has spread, it can be more difficult to treat.

Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.

Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.

In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.

Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.

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