Ti pathophysiology ti kanser iti bagis tuktukoyenna dagiti kangrunaan a mekanismo ken proseso a mangiturong iti itatanor ken panagsaknap ti kanser iti bagis.
Ti kanser iti bagis, a pagaammo met kas colorectal cancer, ket maysa a kita ti kanser a mangrugi iti bagis wenno rectum, a paset ti dakkel nga igges.
Gagangay a mangrugi dayta kas maysa a timmubo a maawagan polyp, a mabalin nga agbalin a kanser iti panaglabas ti tiempo.
Ti pathophysiology ti kanser ti bagis ket ramanenna ti sumagmamano a banag, agraman dagiti genetic mutation, inflammation, ken dagiti banag iti aglawlaw.
Mabalin a tumaud dagiti genetic mutation iti DNA dagiti selula ti colon, a mangiturong iti di makontrol a panagdakkel ken panagbingay dagiti selula.
Dagitoy a mutation ket mabalin a matawid wenno maadda, ken mabalin a maapektaran ti nadumaduma a gene a nainaig iti panagdakkel, panagbingay, ken panangtarimaan ti selula.
Ti pannaka-inflamed ti colon, a mabalin a gapu iti inflammatory bowel disease, mabalin met a mangpadakkel iti peggad ti kanser ti colon.
Ti nakaro a panagebbal mabalin nga agresulta iti pannakairuar dagiti kemikal a mangparegta iti panagdakkel ken pannakabingay dagiti selula, a mabalin a mangituggod iti kanser.
Dagiti makagapu iti aglawlaw, kas iti taraon, estilo ti panagbiag, ken pannakaisarang kadagiti kemikal, mabalin met a pakaigapuan ti kanser iti bagis.
Ti taraon a nabaknang iti nalabaga ken naproseso a karne, kas pagarigan, ket nainaig iti ad-adu a peggad iti kanser iti bagis.
Dadduma pay a banag, kas iti kinalukmeg, panagsigarilio, ken kurang a panagehersisio, ti mabalin a mangpakaro iti peggad.
No timmanoren ti kanser iti bagis, mabalin nga agsaknap iti nadumaduma nga addang, manipud iti nasapa nga addang a kanser a naiputputong iti bagis agingga iti ad-adda a rimmang-ayan nga addang a nagsaknapen ti kanser iti dadduma a paset ti bagi.
Dagiti selula ti kanser mabalin a rautenda dagiti asideg a tisyu ken organo, ken mabalin met nga agwarasda babaen ti lymphatic system wenno dara kadagiti adayo a lugar, kas iti dalem wenno bara.
Ti panangagas iti kanser ti bagis ket gagangay a kombinasion ti operasion, chemotherapy, ken radiation therapy, depende iti kasasaad ken ayan ti kanser.
Ti nasapa a panangilasin ken panangagas ket napateg iti panangpasayaat kadagiti resulta, ta masansan a maagasan ti kanser ti bagis no nasapa a madlaw.
Ti regular a panangeksamen, kas iti colonoscopy, makatulong a mangilasin iti kanser iti bagis iti kasapaan a tukadna, a no kasta ket nalaklaka a maagasan.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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