Pathophysiologie ya kansere ya colon ke tendula mambu yina ke salaka nde kansere ya colon kukuma ngolo.
Kansere ya colon, to kansere ya mukongo, kele kansere yina keyantikaka na colon to na mukongo ya nene, yina kele bitini ya misopo ya nene.
Mbala mingi yo keyantikaka na mutindu ya nene yina bo kebingaka polyp, yina lenda kuma kansere na nima ya ntangu.
Kansere ya mukwa ya nene ke vandaka ti mambu mingi, mu mbandu ba mutation ya ba gènes, maladi ya ntu mpi mambu ya ke vandaka na nzyunga.
Ba mutation ya ba gene lenda basika na ADN ya baselile ya colon, mpi yo lenda sala nde baselile kuyela mpi kukabwana kukonda kuyala.
Bima yai lenda basika na nitu to na nitu mosi, mpi yo lenda vanda ti bupusi na ba gène mingi yina kesalaka nde baselile kuyela, kukabwana, mpi kuyidika nitu.
Kubela ya misuni ya nene, yina lenda basika na maladi ya misuni ya nene, lenda sala mpi nde muntu kukuma ti kansere ya misuni ya nene.
Maladi ya ke manaka ve lenda basisa bima yina ke salaka nde baselile kuyela mpi kukabwana, mpi yo lenda sala nde muntu kukuma ti kansere.
Mambu ya nkaka ya luzingu, mu mbandu madia, mutindu ya kuzinga, mpi bima ya nkaka ya ke fwaka, lenda sala mpi nde muntu kukuma ti kansere ya nene.
Mu mbandu, bantu ke tubaka nde kana muntu ke dia mingi misuni ya mbwaki mpi ya bo me sala bansosa sambu na kuzaba kana yo kele nki, yo lenda sala nde yandi kuma ti kansere ya nene.
Mambu yankaka, mu mbandu, nene ya kuluta ndilu, kunwa makaya, mpi kukonda kusala bisalu ya ngolo, lenda sala nde maladi yango kukuma ngolo.
Kana kansere ya mukwa ya nene me yantika, yo lenda kuma na bandonga mingi, banda na bandonga ya ntete yina ke vandaka kaka na mukwa ya nene tii na bandonga ya nsuka yina ke kumaka na bandonga ya nkaka ya nitu.
Baselile ya kansere lenda kota na baselile ya nkaka ya kele pene-pene mpi yo lenda kuma na baselile ya nkaka ya nkaka ya nitu, mpi yo lenda kuma na baselile ya nkaka ya nitu to na menga.
Bo ke salaka operasio, ke pesaka nkisi ya ngolo ya ke fwaka bankisi ya nkaka ya nitu (chimiothérapie) mpi ke pesaka nkisi ya ngolo ya ke fwaka bankisi ya nkaka ya nitu (radiothérapie) sambu na kubelula kansere ya nene ya divumu.
Kana bo zaba maladi yango na luyantiku mpi bo yantika kusansa yo, yo ke sadisaka mingi na kubelula yo.
Kana bo kesadila ekzame mbala na mbala, mu mbandu ekzame ya nene ya divumu, yo lenda sadisa na kuzaba kansere ya divumu na luyantiku, ntangu yo kele mpasi ve na kubelula yo.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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