What is pathophysiology of Prostate cancer?

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Quina es la fisiopatologia del càncer de la prostata?

La fisiopatologia del càncer de la prostata fa referéncia als mecanismes e procediments que menan al desvelopament e a la progression de la malautiá.

Lo càncer de la prostata es una tumor maligna que se constituís de las cellulas de la glandula prostatica, qu'es un organ pichon e en forma de notz situat jos la veissiga dels òmes.

La glandula prostatica produch de liquid seminal, que noirís e transpòrta l'esperma.

La causa exacta del càncer de la prostata es pas plan compresa, mas se sap que diferents factors aumentan lo risc de desvelopar la malautiá.

Aqueles incluson l'edat, istòria familiala, raça, e de mutacions geneticas.

Lo càncer de la prostata es mai comun pels òmes d'edat, amb la majoritat dels cases dins los òmes de mai de 65 ans.

Mai, los òmes amb d'anamnèsi familiala de càncer de la prostata son a risc, coma los òmes afroamericans e d'origina cariba.

La fisiopatologia del càncer de la prostata implica la creissença e division incontroladas de las cellulas dins la glandula prostatica.

Aquò pòt se produire a causa de mutacions geneticas que menan a la suberexpression de factors de creissença o a l'inactivacion de gèns supressors de tumors.

Aquelas mutacions pòdon provocar la creissença non regulada de las cellulas, menant a la formacion d'una tumor.

A mesura que la tumor grandís, pòt envasir los teissuts e organs pròches, coma la veissiga, lo recte, e los ganglions linfàtics.

Dins unes cases, las cellulas cancerosas se pòdon separar de la tumor primària e espandir a d'autras partidas del còrs mejans la sang o lo sistèma linfatic, un procediment conegut coma metastasi.

Un còp que lo càncer s'es espandit, pòt èsser mai dificil de lo tractar.

Lo càncer de la prostata pòt tanben èsser influenciat per de factors ormonals, subretot l'ormona androgèna testosterona.

La testosterona pòt estimular la creissença de las cellulas del càncer de la prostata, e fòrça tractaments pel càncer de la prostata an per objectiu de reduire los nivèls d'aquela ormona o blocar sos efièchs.

En resumit, la fisiopatologia del càncer de la prostata implica la creissença e division incontroladas de las cellulas dins la glandula prostatica, que pòt èsser influenciada per de factors genetics, ormonals, e environamentals.

Comprendre los mecanismes de basa de la malautiá es crucial per desvolopar de tractaments eficaces e melhorar los resultats pels pacients amb càncer de la prostata.

['Referéncias']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Zobniw CM, Causebrook A, Fong MK: Clinical use of abiraterone in the treatment of metastatic castration-resistant prostate cancer. Res Rep Urol. 2014, 6 (): 97-105.

Lim HY, Agarwal AM, Agarwal N, Ward JH: Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J. 2009, 50 (5): e178-80.

Kohli M, Qin R, Jimenez R, Dehm SM: Biomarker-based targeting of the androgen-androgen receptor axis in advanced prostate cancer. Adv Urol. 2012, 2012 (): 781459.

Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW: Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995, 1 (9): 944-9.

Msaouel P, Nandikolla G, Pneumaticos SG, Koutsilieris M: Bone microenvironment-targeted manipulations for the treatment of osteoblastic metastasis in castration-resistant prostate cancer. Expert Opin Investig Drugs. 2013, 22 (11): 1385-400.

Kotani K, Sekine Y, Ishikawa S, Ikpot IZ, Suzuki K, Remaley AT: High-density lipoprotein and prostate cancer: an overview. J Epidemiol. 2013, 23 (5): 313-9.

Jadvar H: Molecular imaging of prostate cancer: a concise synopsis. Mol Imaging. , 8 (2): 56-64.

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What is pathophysiology of prostate cancer?

The pathophysiology of prostate cancer refers to the underlying mechanisms and processes that lead to the development and progression of the disease.

Prostate cancer is a malignant tumor that arises from the cells of the prostate gland, which is a small, walnut-shaped organ located below the bladder in men.

The prostate gland produces seminal fluid, which nourishes and transports sperm.

The exact cause of prostate cancer is not fully understood, but several factors are known to increase the risk of developing the disease.

These include age, family history, race, and certain genetic mutations.

Prostate cancer is more common in older men, with the majority of cases occurring in men over the age of 65.

Additionally, men with a family history of prostate cancer are at an increased risk, as are African American men and men of Caribbean descent.

The pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland.

This can occur due to genetic mutations that lead to the overexpression of certain growth factors or the inactivation of tumor suppressor genes.

These mutations can result in the unregulated growth of cells, leading to the formation of a tumor.

As the tumor grows, it can invade nearby tissues and organs, such as the bladder, rectum, and nearby lymph nodes.

In some cases, cancer cells can break away from the primary tumor and spread to other parts of the body through the bloodstream or lymphatic system, a process known as metastasis.

Once the cancer has spread, it can be more difficult to treat.

Prostate cancer can also be influenced by hormonal factors, particularly the androgen hormone testosterone.

Testosterone can stimulate the growth of prostate cancer cells, and many treatments for prostate cancer aim to reduce the levels of this hormone or block its effects.

In summary, the pathophysiology of prostate cancer involves the uncontrolled growth and division of cells within the prostate gland, which can be influenced by genetic, hormonal, and environmental factors.

Understanding the underlying mechanisms of the disease is crucial for developing effective treatments and improving outcomes for patients with prostate cancer.

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