E fisiopatologia di kanser na pechu ta referí na e kambionan anormal den e prosesonan i mekanismo fisiológiko normal ku ta tuma lugá den desaroyo i progreso di kanser na pechu.
E ta enserá estudio di e mekanismo biológiko i molekular ku ta kondusí na kresementu i plamamentu di sèlnan di kanser den e tejido di pechu.
Esaki ta inclui e factornan genetico, epigenetico y ambiental cu ta contribui na e inicio, promocion y progreso di cancer di pecho.
Algun di e kambionan fisiopatológiko klave den kanser na pechu ta:
1. Mutashon genétiko: Mutashon den sierto gen, manera BRCA1 i BRCA2, por oumentá e riesgo di desaroyá kanser na pechu.
E mutashonnan aki por wòrdu heredá òf adkiri durante bida di un persona.
2. Desbalanse hormonal: Hormonnan, partikularmente estrogen, por hunga un ròl den desaroyo i kresementu di kanser na pechu.
Un desbalansa den e nivel di hormona of exposicion na un exceso di estrogen por aumenta e riesgo di cancer di pecho.
Inflamacion: Inflamacion cronico den e tehido di pecho por contribui na desaroyo di cancer di pecho door di promove e crecemento y sobrevivencia di celnan canceroso.
4. Mikroambiente di e tumor: E ambiente rondó di e tumor, inkluyendo e matriz ekstracelular, e sèlnan di e sistema inmunológiko i e vasonan di sanger, por influensiá kresementu i plamamentu di kanser na pechu.
5. Metastasis: Kanser na pechu por plama na otro parti di kurpa via e sistema limfatiko òf e sistema di sirkulashon di sanger, loke ta kondusí na formashon di tumor sekundario den órgano leu.
Komprondé e fisiopatologia di kanser na pechu ta krusial pa desaroyá prevenshon efektivo, detekshon trempan i strategianan di tratamentu.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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