Pathophysiology ea kankere ea matsoele e bolela liphetoho tse sa tloaelehang lits'ebetsong le mekhoeng e tloaelehileng ea'mele e hlahang ho nts'etsopele le tsoelo-pele ea kankere ea matsoele.
E akarelletsa ho ithuta mekhoa ea tlhaho le ea limolek'hule e bakang ho hōla le ho ata ha lisele tsa kankere ka har'a lisele tsa matsoele.
Sena se akarelletsa liphatsa tsa lefutso, liphatsa tsa tlhaho le tikoloho tse tlatsetsang ho qaleheng, ho eketseheng le ho mpefatseng ha kankere ea matsoele.
Liphetoho tse ling tsa bohlokoa tsa pathophysiological kankere ea matsoele li kenyelletsa:
1. Liphetoho tsa liphatsa tsa lefutso: Liphetoho liphatseng tse itseng tsa lefutso, tse kang BRCA1 le BRCA2, li ka eketsa kotsi ea ho tšoaroa ke kankere ea matsoele.
Liphetoho tsena li ka futsetsoa kapa tsa fumanoa nakong ea bophelo ba motho.
Ho se leka-lekane ha lihormone: Lihormone, haholo-holo estrogen, li ka ba le karolo ho hlaheng le ho hōleng ha kankere ea matsoele.
Ho se leka - lekane ha lihormone kapa ho ba le estrogen e ngata haholo ho ka eketsa kotsi ea ho tšoaroa ke kankere ea matsoele.
3. Ho ruruha: Ho ruruha ho sa foleng ha lisele tsa matsoele ho ka etsa hore motho a be le kankere ea matsoele ka hore ho etse hore lisele tsa kankere li hōle le ho phela.
4. Tikoloho e potolohileng hlahala: Tikoloho e potolohileng hlahala, ho akarelletsa le lisele tse ka ntle ho sele, lisele tse sireletsang'mele le methapo ea mali, e ka susumetsa ho hōla le ho ata ha kankere ea matsoele.
5. Metastasis: Kankere ea matsoele e ka namela likarolong tse ling tsa'mele ka tsamaiso ea lymphatic kapa ka mali, e lebisang ho thehoeng ha lihlahala tse ling lithong tse hōle.
Ho utloisisa pathophysiology ea kankere ea matsoele ke habohlokoa bakeng sa ho etsa mekhoa e sebetsang ea ho thibela, ho lemoha kapele le ho phekola.
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Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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["le (6) ho saena ka letsoho kapa ka elektronike ha mong'a litokelo tsa bangoli kapa motho ea lumeletsoeng ho nka khato lebitsong la mong'a litokelo tsa bangoli. "]
['Ho hloleha ho kenyelletsa tlhahisoleseding yohle e ka hodimo ho ka baka ho dieha ha ho sebetswa tletlebo ya hao.']
['Ho Iteanya']
['Ka kōpo re romelle imeile ka potso / tlhahiso leha e le efe.']
What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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