Urticaria, e tsejoang ka hore ke lekhopho, ke boemo ba letlalo bo khetholloang ke ho hlaha ha makhopho a mafubelu a hlohlona, a phahametseng letlalo.
Pathophysiology ea urticaria e akarelletsa ho lokolloa ha histamine le lintho tse ling tse bakang ho ruruha ho tsoa liseleng tse khōlō, e leng lisele tse sireletsang'mele tse fumanoang letlalong le liseleng tse ling.
Ha motho a e - na le urticaria e matla, histamine le lintho tse ling tse bakang ho ruruha ha letlalo li tsoa ha a tšoaroa ke ntho e itseng e etsang hore a be le ho ruruha, e kang lijo, meriana kapa ho longoa ke likokoanyana.
Sena se etsa hore lisele tse khōlō li se ke tsa ba le granules, li ntše histamine le lintho tse ling tse etsang hore methapo ea mali e bulehe, e leng se etsang hore ho be le mabali.
Ha motho a e - na le urticaria e sa foleng, hangata sesosa ha se tsejoe, empa ho nahanoa hore se bakoa ke tsamaiso ea'mele ea ho itšireletsa mafung.
Tabeng ena,'mele o hlahisa li-autoantibodies tse lebisang ho li-receptor tsa IgE tse nang le kamano e phahameng (FcεRI) liseleng tsa mast, tse lebisang ts'ebetsong ea tsona le ho lokolloa ha histamine le baemeli ba bang.
Ka bobeli ha ho e - ba le urticaria e matla le e sa foleng, ho lokolloa ha histamine le lintho tse ling tse bakang lefu lena ho baka matšoao a ho hlohlona, ho khubelu le ho ruruha.
Hangata kalafo e akarelletsa ho sebelisa li-antihistamine ho thibela liphello tsa histamine le ho fokotsa matšoao.
Maemong a matla, meriana e meng e kang corticosteroids kapa omalizumab e ka sebelisoa ho laola boemo.
Wahlgren CF: Pathophysiology of itching in urticaria and atopic dermatitis. Allergy. 1992, 47 (2 Pt 1): 65-75.
Raap U, Liekenbröcker T, Wieczorek D, Kapp A, Wedi B: [New therapeutic strategies for the different subtypes of urticaria]. Hautarzt. 2004, 55 (4): 361-6.
[Recommendations for the diagnosis and treatment of urticaria in children]. Arch Argent Pediatr. 2021, 119 (2): S54-S66.
Brzoza Z, Grzeszczak W, Rogala B, Trautsolt W, Moczulski D: Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria. Allergol Immunopathol (Madr). , 42 (4): 302-6.
Sweeney TM, Dexter WW: Cholinergic urticaria in a jogger: ruling out exercise-induced anaphylaxis. Phys Sportsmed. 2003, 31 (6): 32-6.
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What is pathophysiology of urticaria?
Urticaria, commonly known as hives, is a skin condition characterized by the appearance of itchy, raised, red welts (wheals) on the skin.
The pathophysiology of urticaria involves the release of histamine and other inflammatory mediators from mast cells, which are immune cells found in the skin and other tissues.
In acute urticaria, the release of histamine and other mediators is triggered by an allergic reaction to a specific allergen, such as food, medication, or insect sting.
This causes the mast cells to degranulate, releasing histamine and other mediators that cause blood vessels to become leaky, leading to the formation of wheals.
In chronic urticaria, the cause is often unknown, but it is thought to be related to an autoimmune mechanism.
In this case, the body produces autoantibodies that target the high-affinity IgE receptor (FcεRI) on mast cells, leading to their activation and the release of histamine and other mediators.
In both acute and chronic urticaria, the release of histamine and other mediators leads to the characteristic symptoms of itching, redness, and swelling.
Treatment typically involves the use of antihistamines to block the effects of histamine and reduce symptoms.
In severe cases, other medications such as corticosteroids or omalizumab may be used to control the condition.
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