What causes Colon cancer?

['Reetsa tsebe eno']

Ke eng se se bakang kankere ya mala?

Kankere ya mogodu, e gape e bidiwang kankere ya mala, e bakwa ke go gola go go sa laolegeng ga disele tse di sa tlwaelegang mo mogodung kgotsa mo maleng.

Se se bakang kankere ya mogodu ga se itsiwe, mme go na le dilo di le mmalwa tse di ka dirang gore motho a nne mo kotsing ya go tshwarwa ke bolwetse jono.

Tseno di akaretsa:

1. Dingwaga: Kotsi ya go tshwarwa ke kankere ya mala e oketsega fa motho a ntse a gola, mme gantsi e tshwara batho ba ba nang le dingwaga tse di fetang 50.

2. Go nna le kankere mo lelapeng: Fa motho a na le kankere ya mala kana dipholipisi mo lelapeng kgotsa a na le tsone mo go ene, seo se ka dira gore a nne mo kotsing ya go tshwarwa ke bolwetse jono.

3. Malwetse a a tshelanwang: Malwetse mangwe a a tshelanwang a dijini, a a jaaka familial adenomatous polyposis (FAP) le hereditary non-polyposis colorectal cancer (HNPCC), a ka oketsa kotsi ya go tshwarwa ke kankere ya mala.

4. Tsela e motho a tshelang ka yone: Go ja nama e khibidu le e e dirilweng ka dilo tse di farologaneng, go nona, go goga le go nwa bojalwa thata go ka dira gore motho a nne mo kotsing ya go tshwarwa ke kankere ya mala.

5. Bolwetse jwa go ruruga ga mala: Malwetse a mala a a sa foleng a a jaaka ulcerative colitis le Crohn's disease, a ka oketsa kotsi ya go tshwarwa ke kankere ya mala.

6. Bolwetse jwa sukiri jwa Type 2: Batho ba ba nang le bolwetse jwa sukiri jwa type 2 ba mo kotsing e kgolo ya go tshwarwa ke kankere ya mala.

7. Kalafi ya marang: Kalafi ya marang ya dikankere tse dingwe tsa mpa e ka oketsa kotsi ya go tshwarwa ke kankere ya mala.

8. Lotso: Ba-Afrika ba ba nnang kwa Amerika ba mo kotsing e kgolwane ya go tshwarwa ke kankere ya mala go feta ba ditso tse dingwe.

Go botlhokwa go lemoga gore go nna le sengwe kgotsa go feta sa dilo tseno tse di bakang kotsi ga go reye gore motho o tla nna le kankere ya mogodu, mme batho bangwe ba ba nnang le kankere ya mogodu ba ka tswa ba se na dilo tse di bakang kotsi.

Go tlhatlhobiwa gangwe le gape le go lemogiwa go sa le gale go ka thusa go thibela kankere ya mala kgotsa go e lemoga e sa ntse e simologa fa e sa ntse e ka alafega motlhofo.

['Ditshupiso']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

['Go se ikarabele: kalafi']

['Web site eno e diretswe go ruta le go naya tshedimosetso fela mme ga e neye kgakololo ya kalafi kgotsa ditirelo tsa seporofešenale.']

['Tshedimosetso e e neelwang ga e a tshwanela go dirisiwa go bona bolwetse kana go alafa bothata jwa botsogo, mme batho ba ba batlang kgakololo ya kalafi ba tshwanetse go ikgolaganya le ngaka e e nang le laesense.']

['Tsweetswee ela tlhoko gore thulaganyo ya methapo e e dirang dikarabo tsa dipotso tseno, ga e a tlhomama fa go tla mo dilong tsa dipalo. Ka sekai, palo ya batho ba ba nang le bolwetse bongwe jo bo rileng.']

['Ka metlha batla kgakololo ya ngaka ya gago kgotsa moabi yo mongwe wa kalafi yo o tshwanelegang malebana le boemo jwa kalafi. Le ka motlha o se ka wa itlhokomolosa kgakololo ya kalafi ya porofeshenale kgotsa wa diega go e batla ka ntlha ya sengwe se o se badileng mo website eno. Fa o akanya gore o ka tswa o na le boemo jwa tshoganyetso jwa kalafi, leletsa 911 kgotsa o ye kwa kamoreng ya tshoganyetso e e gaufi le wena ka bonako. Ga go na kamano epe ya ngaka le molwetse e e tlisiwang ke website eno kgotsa go e dirisa. BioMedLib kgotsa badiri ba yone, kgotsa ope fela yo o tsentseng letsogo mo website eno, ga ba dire ditshupetso dipe, tse di tlhamaletseng kgotsa tse di sa tlhamalalang, malebana le tshedimosetso e e mo go yone kgotsa go e dirisa.']

['Go ikgatholosa: ditshwanelo tsa bokwadi']

['Molao wa Digital Millennium Copyright wa 1998, 17 U.S.C. § 512 (the DMCA) o tlamela ka kgetse ya beng ba ditshwanelo ba ba dumelang gore matheriale o o tlhagelelang mo inthaneteng o gataka ditshwanelo tsa bona go ya ka molao wa ditshwanelo wa U.S.']

['Fa o dumela ka pelo yotlhe gore tshedimosetso kgotsa matheriale o o mo website ya rona kgotsa ditirelo tsa rona o gataka ditshwanelo tsa gago tsa semolao, wena (kgotsa moemedi wa gago) o ka re romelela kitsiso o kopa gore tshedimosetso eo kgotsa matheriale oo o tlosiwe kgotsa o thibelwe go o fitlhelela.']

['Dikitsiso di tshwanetse go romelwa ka go kwala ka imeili (leba karolo ya "Contact" go bona aterese ya imeili).']

['DMCA e batla gore kitsiso ya gago ya go tlolwa ga ditshwanelo tsa gago e akaretse tshedimosetso e e latelang: (1) tlhaloso ya tiro e e sireleditsweng ka ditshwanelo e go tweng e tlotswe; (2) tlhaloso ya diteng tse go tweng di tlotswe le tshedimosetso e e lekaneng go re letla go bona diteng; (3) tshedimosetso ya go ikgolaganya le wena, go akaretsa aterese ya gago, nomoro ya mogala le aterese ya imeile; (4) polelo ya gago ya gore o dumela ka pelo yotlhe gore diteng tse di tlotsweng ga di a letlelelwa ke mong wa ditshwanelo tsa gago, kgotsa moemedi wa gagwe, kgotsa ka molao ope; ']

['(5) polelo e e saenilweng ke wena, e e supang gore tshedimosetso e e mo kitsisong e boammaaruri le gore o na le thata ya go diragatsa ditshwanelo tsa botaki tse go tweng di gatakilwe;']

['le (6) saena ya mmatota kgotsa ya eleketeroniki ya mong wa tshwanelo ya go gatisa kgotsa motho yo o filweng tetla ya go dira mo boemong jwa mong wa tshwanelo ya go gatisa. ']

['Fa o sa akaretse tshedimosetso yotlhe e e fa godimo e ka nna ya diegisa go sekasekwa ga ngongorego ya gago.']

['Go Ikgolaganya']

['Tsweetswee re romelele imeile ka potso/kgakololo epe fela.']

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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