Pathophysiology ya kankere ya mogodu e kaya mekgwa le ditsamaiso tse di bakang gore go nne le kankere ya mogodu.
Kankere ya mogodu, e gape e itsegeng jaaka kankere ya mala, ke mofuta wa kankere e e simololang mo mogodung kgotsa mo thitong, e leng dikarolo tsa mala a magolo.
Gantsi bo simolola e le go gola go go bidiwang polyp, mo go ka nnang ga fetoga kankere fa nako e ntse e ya.
Pathophysiology ya kankere ya mogodu e akaretsa dilo di le mmalwa, go akaretsa le go fetoga ga dijini, go ruruga le dilo tse di amanang le tikologo.
Go ka nna le diphetogo tsa dijini mo DNA ya disele tsa mogodu, tse di ka dirang gore disele di gole di bo di kgaogane ka tsela e e sa laolesegeng.
Diphetogo tseno di ka nna tsa bo di tswa mo batsading kgotsa di ka nna teng ka ntlha ya go bo motho a na le tsone, mme di ka ama dijini tse di farologaneng tse di thusang disele go gola, go ikgaoganya le go intšhafatsa.
Go ruruga ga mogodu, mo go ka bakiwang ke maemo a a jaaka bolwetse jwa go ruruga ga mogodu, le gone go ka oketsa kotsi ya go tshwarwa ke kankere ya mogodu.
Go ruruga go go sa foleng go ka dira gore go nne le dikhemikale tse di dirang gore disele di gole le go ikgaoganya, mme seo se ka dira gore motho a nne le kankere.
Dilo tse di amang tikologo, tse di jaaka dijo tse motho a di jang, tsela e a tshelang ka yone le go kopana le dikhemikale dingwe, le tsone di ka dira gore motho a nne le kankere ya mala.
Ka sekai, go ja nama e khibidu le e e dirilweng ka nama go amanngwa le go nna mo kotsing ya go tshwarwa ke kankere ya mala.
Dilo tse dingwe tse di jaaka go nona thata, go goga motsoko le go sa itshidile mmele le tsone di ka oketsa kotsi ya go tshwarwa ke bolwetse jono.
Fa kankere ya mogodu e setse e simolotse, e ka fetela mo dikgatong di le mmalwa, go simolola ka kankere ya mo tshimologong e e fitlhelwang fela mo mogodung go fitlha mo kgatong e e kwa pele e e anametseng kwa dikarolong tse dingwe tsa mmele.
Disele tsa kankere di ka tlhasela dithishu le dirwe tse di gaufi, mme gape di ka anama ka thulaganyo ya lymphatic kgotsa ka madi go ya kwa mafelong a a kgakala, a a jaaka sebete kgotsa makgwafo.
Kalafi ya kankere ya mogodu gantsi e akaretsa go ariwa, go alafiwa ka dikhemikale le ka marang, go ikaegile ka gore kankere e mo kgatong efe le gore e mo lefelong lefe.
Go lemoga kankere e sa ntse e simologa le go e alafa go botlhokwa thata gore e alafiwe ka bonako, ka gonne gantsi kankere ya mogodu e a alafega fa e lemogilwe e sa ntse e simologa.
Go tlhatlhoba mala ka metlha, jaaka go tlhatlhoba mala, go ka thusa go lemoga kankere ya mala e sa ntse e simologa, ka nako ya fa e ka alafega motlhofo.
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Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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['(5) polelo e e saenilweng ke wena, e e supang gore tshedimosetso e e mo kitsisong e boammaaruri le gore o na le thata ya go diragatsa ditshwanelo tsa botaki tse go tweng di gatakilwe;']
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['Tsweetswee re romelele imeile ka potso/kgakololo epe fela.']
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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