Kolon raky, kolorektal rak hökmünde hem tanalýan, kolonda ýa-da rektumda anormal öýjükleriň kontrolsuz ösüşi sebäpli döreýär.
Gürçülik rakynyň anyk sebäbi belli däl, ýöne birnäçe faktorlar keselçiligiň döremegi mümkinçiligi artdyrýar.
Bularyň arasynda:
1. Ýaş: gartaşan adamlarda garyn içegesi raky mümkinçiligi artýar.
2. Maşgala taryhy: Maşgalada ýa-da şahsy taryhyda garynça raky ýa-da polipler bolan adamda bu kesel bolmagyň mümkinçiligi artýar.
3. Miras alan keselçilikler: käbir miras alan genetik keselçilikler, meselem, maşgalada bolan adenomatöz polipoz (FAP) we miras alan polipozsuz kolorektal rak (HNPCC) ýaly keselçilikler garyn içeginiň rak howplylygyny artdyrýar.
4. Durmuş şertleri: Köp et iýmek, semizlik, çilim çekmek we spirtli içgileri köp içmek garyn rak keseline eltip biler.
5. Içeginiň ýagyşly keselligi: Içeginiň ýagyşly keselligi we Kron keselligi ýaly uzak wagtlap dowam edýän kesellikler içeginiň rak howply ýagdaýyny has-da artdyrýar.
6. 2-nji görnüşli diabet: 2-nji görnüşli diabetli adamlaryň garyn içegesi rak keseline uçramagy mümkin.
7. Şöhleli bejergi: Karyn içindäki başga raklara şöhleli bejergi bermek garyn içi rakynyň bolmagynyň mümkinçiligini artdyrýar.
8. Irk: Afrikalı-amerikalılarda garyn içegesi rakynyň döremegi mümkinçiligi başga milletlere garanyňda köp.
Bu bir ýa-da birnäçesi bu howply faktorlaryň bolmagynyň adamyň kolon raky bilen kesellejekdigi aňlatmaýandygyny we kolon raky bilen keselleýän käbir adamlaryň hiç hili howply faktorlary bolmaýandygyny unutmaly däl.
Yzygiderli barlamak we irden anyklamak garyn rakynyň öňüni almaga kömek edýär ýa-da ony dermanlap bolýan wagtynda anyklaýar.
McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.
Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.
Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.
Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.
Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.
Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.
Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.
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['5) Siziň ýalan sözlemek jezasy astynda gol çekip, habarlamada berilýän maglumatyň dogrydigini we siziň bozulan diýip aýyplanýan avtorlyk hukugyny goramaga ygtyýaryňyzyň bardygyny tassyklaýan şaýatlygyňyz;']
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What causes colon cancer?
Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.
The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.
These include:
1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.
2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.
3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.
4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.
5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.
6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.
7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.
8. Race: African Americans have a higher risk of developing colon cancer than other races.
It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.
Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.
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