Gür içeginiň rak keseliniň patofiziologiyasy näme?
Kolon rakynyň patofiziologiyasy kolon rakynyň döremegine we ilerlemesine getirýän esas mexanizmleri we proseslerini aňladýar.
Kolon raky, kolorektal rak hökmünde hem tanalýan, ýygyndan barmakda ýa-da rektumda başlanýan rak görnüşidir.
Bu köplenç polip diýen ösüş bilen başlaýar, wagtyň geçmegi bilen rak bolup ösüp bilýär.
Kolon rakynyň patofiziologiyasy birnäçe faktorlary öz içine alýar, şol sanda genetik mutasiyalar, ýitgi we daşky şertler.
Genetik mutasiýalar kolon öýjükleriniň DNA-synda bolup, öýjükleriň kontrolsuz ösüşine we bölünmegine eltýär.
Bu türlenmeler miras alnyp ýa-da edinip biler we olar öýjük ösüşi, bölünişi we bejerişinde rol oýnaýan dürli genlere täsir edip biler.
Içeginiň ýagyşly keselinden döräp biljek garyn içeginiň ýagyşy hem garyn içeginiň rak howplulygyny artdyryp biler.
Kronik ýagyşlyk öýjük ösüşini we bölünişini artdyrýan, rak ösüşine eltýän himiýalary döredip biler.
Daş-töwerek faktorlary, meselem, iýmit, ýaşaýş usuly we käbir himiýalary ulanmaklyk hem garynça rakynyň döremegine goşant goşýar.
Mysal üçin, köp gyzyl we işlenmiş et iýmitleri garynça rakynyň artýan howpludygy bilen baglanyşdyrylýar.
Şeýle - de semizlik, çilim çekmek we beden taýdan hereketsizlik ýaly başga - da zatlar hem bu keselçiligiň köpelmegine sebäp bolup biler.
Bir gezek ýokary içegäniň raky dörände, ol birnäçe stadiýa geçip biler, ýokary içegäniň rakdan başlap, rak bedeniň başga böleklerine ýaýran has ilerleýen stadiýa çenli.
Kanser öýjükleri golaýdaky dokulara we organlara hüjüm edip biler we limfa sistemasy ýa-da gan akymy arkaly uzak ýerlere, meselem, ýürek ýa-da akcigerlere ýaýrap biler.
Gür içeginiň rak keseliniň bejerişine adaty usul bilen operasiýa, himioterapiýa we şöhle terapiýasy goşulýar.
Erken anyklanmak we bejermek netijeleri gowulandyrmak üçin esasy zat, çünki ýokary içegäniň raky köplenç erkindik därejesinde anyklananda bejerilýändir.
Kolonoskopiya ýaly yzygiderli barlaglar, ýygyndy keselini dermanly wagtynda anyklamaga kömek edýär.
Vidal-Vanaclocha F: The liver prometastatic reaction of cancer patients: implications for microenvironment-dependent colon cancer gene regulation. Cancer Microenviron. 2011, 4 (2): 163-80.
Yagi T, Kubota E, Koyama H, Tanaka T, Kataoka H, Imaeda K, Joh T: Glucagon promotes colon cancer cell growth via regulating AMPK and MAPK pathways. Oncotarget. 2018, 9 (12): 10650-10664.
Sharma SH, Thulasingam S, Nagarajan S: Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives. Eur J Pharmacol. 2017, 795 (): 169-178.
Keshk WA, Zineldeen DH, Wasfy RE, El-Khadrawy OH: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. Med Oncol. 2014, 31 (10): 192.
Dongfeng D, An C, Shujia P, Jikai Y, Tao Y, Rui D, Kai T, Yafeng C, Jianguo L, Xilin D: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids. Afr Health Sci. 2014, 14 (4): 925-8.
Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
['Ýagşylykdan ýüz öwürmek: medisina']
['Bu web - saýt diňe bilim we maglumat bermek üçin niýetlenen.']
['Berilen maglumat saglyk meselesini ýa-da keselini anyklamak ýa-da bejermek üçin ulanmaly däl we şahsy lukman maslahatyny gözleýänler lukman bilen maslahatlaşmaly.']
['Soragyň jogabyny döredýän sinir tory sanly maglumat babatda nädogry bolup biler.']
['Her wagt lukmanyňyzyň ýa-da başga bir saglyk hyzmatçysynyň maslahatyny sorap görüň. Bu web-saýtda okan zadyňyz üçin hiç haçan lukmanlaryň maslahatyny äsgermezlik etmäň ýa-da ony soramaga soňa goýmaň. Eger sizde medisina ýagdaýy kyn bolsa, 911-e jaň ediň ýa-da derrew iň golaýdaky hassahana baryň. Bu web-saýt ýa-da onuň ulanylyşy bilen lukman-hassa gatnaşygy döremeýär. BioMedLib-de, onuň işgärleri-de, ýa-da bu web-saýtda goşant goşýanlar-da, bu ýerde berilýän maglumat ýa-da onuň ulanylyşy babatda hiç hili açyk ýa-da örtülü wekilçilik etmeýärler.']
['Ýokary haklar']
['1998-nji ýylyň Digital Millennium Copyright Act, 17 U.S.C. § 512 (DMCA) haky bolanlar üçin Internetde görünýän materiallary ABŞ haky boýunça hukuklaryny bozýar diýip pikir edýänlere çäre görmäge mümkinçilik berýär. ']
['Eger siz biziň web saýtymyz ýa-da hyzmatlarymyz bilen baglanyşykly edip berilýän maglumat ýa-da materiallaryň siziň avtorlyk hukugyňyzy bozýandygyny dogry ynansaňyz, siz (ýa-da wekiliňiz) maglumat ýa-da materiallary aýyrmak ýa-da olara girmegiň bökülmegi barada bize habarlama ýollap bilersiňiz.']
['Habarlamalar elektron poçta arkaly ýazylgy ýollanmaly (elektron poçta jaýyny görmek üçin "Mugallymlar" bölüminde seret).']
['DMCA nusgasyna görä, hakyňy bozmak barada habar bermegiňde şu maglumatlar gerek: (1) hakyňy bozmakda aýyplanýan hakyňy goraýan işiň suratlandyrmasy; (2) hakyňy bozýan maglumatyň suratlandyrmasy we maglumaty tapmaga ýeterlik maglumat; (3) seniň bilen habarlaşmak üçin maglumat, şol sanda seniň adres, telefon we elektron poçtalaryň; (4) seniň hakyňy bozýan maglumatyň hak eýesi ýa-da onuň wekili tarapyndan ýa-da kanun boýunça rugsat berilmändigine gowy ynamyň bardygy barada şaýatlyk.']
['5) Siziň ýalan sözlemek jezasy astynda gol çekip, habarlamada berilýän maglumatyň dogrydigini we siziň bozulan diýip aýyplanýan avtorlyk hukugyny goramaga ygtyýaryňyzyň bardygyny tassyklaýan şaýatlygyňyz;']
['we (6) hak eýesiniň ýa-da hak eýesi adyndan hereket etmäge ygtyýary bolan adamyň fiziki ýa-da elektron goly. ']
['Eger ýokarda agzalan maglumatlaryň ählisini ýazmasaň, şikayetleriňiň çözülmegi giçleşdiriler.']
['Baglanyş']
['Haýsy soragyňyz / teklibiňiz bar bolsa bize email ýollaň.']
What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
Disclaimer: medical
This web site is provided for educational and informational purposes only and does not constitute providing medical advice or professional services.
The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.
Please note the neural net that generates answers to the questions, is specially inaccurate when it comes to numeric content. For example, the number of people diagnosed with a specific disease.
Always seek the advice of your doctor or other qualified health provider regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. If you think you may have a medical emergency, call 911 or go to the nearest emergency room immediately. No physician-patient relationship is created by this web site or its use. Neither BioMedLib nor its employees, nor any contributor to this web site, makes any representations, express or implied, with respect to the information provided herein or to its use.
Disclaimer: copyright
The Digital Millennium Copyright Act of 1998, 17 U.S.C. § 512 (the “DMCA”) provides recourse for copyright owners who believe that material appearing on the Internet infringes their rights under U.S. copyright law. If you believe in good faith that any content or material made available in connection with our website or services infringes your copyright, you (or your agent) may send us a notice requesting that the content or material be removed, or access to it blocked. Notices must be sent in writing by email (see 'Contact' section for email address) . The DMCA requires that your notice of alleged copyright infringement include the following information: (1) description of the copyrighted work that is the subject of claimed infringement; (2) description of the alleged infringing content and information sufficient to permit us to locate the content; (3) contact information for you, including your address, telephone number and email address; (4) a statement by you that you have a good faith belief that the content in the manner complained of is not authorized by the copyright owner, or its agent, or by the operation of any law; (5) a statement by you, signed under penalty of perjury, that the information in the notification is accurate and that you have the authority to enforce the copyrights that are claimed to be infringed; and (6) a physical or electronic signature of the copyright owner or a person authorized to act on the copyright owner’s behalf. Failure to include all of the above information may result in the delay of the processing of your complaint.
['Hakkynda']
['BioMedLib sorag-jawaplaryň döremegine avtomatlaşdyrylan kompýuterleri ulanýar (maşyn öwrenilýän algoritmler).']
['Biz PubMed/Medline-den 35 million sany biomedikal neşirleri we RefinedWeb-den web sahypalary bilen başlaýarys.']
