Şekerli kesel patofizýologýasy şekerli keseliniň döremegine getirýän tertipsiz fiziologik prosesleri öwrenmegi aňladýar.
Şekerli kesel insuliniň sekresiýasy, insuliniň hereket edişi ýa-da ikisiniň hem nädogry işlenmeginden döreýän glikoz (glikoz) derejesiniň ýokary bolmagy bilen suratlandyrylýan metabolik keselçilikleriň toparydyr.
Şekerli keseliniň patofiziologiyasy keselçiligiň döremegine goşant goşýan genetik, daşky we ýaşaýş usuly amilleriniň murekkep täsirleşmegini öz içine alýar.
1- nji tip diabetde patofiziologiýa pankreasyň insulin emele getirýän beta öýjükleriniň otoimmün ýok edilmegine degişli bolup, insulin emele getirmekde ýetmezçilige eltýär.
Bu gan şekeri derejesini düzedip bilmeýänlige getirýär, bu bolsa giripglisemiýa (ganyň joşgunly şekeri) getirýär.
2-nji tip diabetde patofiziologiya has çylşyrymly bolup hem insulin garşylygy hem insulin sekresiýasynyň bozulmagyny öz içine alýar.
Insulin garşylygy beden öýjükleri insulyna dogry jogap bermänlerinde bolup, bu glukozany energiýa üçin netijeli ulanmaga ukypsyzlyga eltýär.
Bu pankreasyň inkär etmegiň öňüni almak üçin köp insulin öndürmegine sebäp bolýar, ýöne wagt geçdigi bilen pankreas talap bilen deňäp bilmän, insulin öndürilmesiniň peselmegine eltýär.
Göwrelilikde döreýän göwrelilik şekeri insulyna garşylyk döredýän gormonal üýtgäplikleri sebäpli döreýär.
Plasenta insuliniň hereketini togtatýan gormonlary emele getirýär we bu glikoz derejesiniň artmagyna eltýär.
Şekerli keseliniň patofiziologiyasy hem agyrlaşmalar bilen baglanyşykly bolup, gan damarlaryna, nervlere we organa zyýan ýetirýär, bu bolsa agyr keselçiliklere eltip biler, meselem, ýürek keselligi, ýokanç, böwrek keselligi we görme gowşamagy.
Şekerli keseliniň patofiziologiyasyny bilmek bu agyr kesel üçin netijeli bejergi we öňüni alyş strategiýasyny döretmek üçin örän wajypdyr.
Biochemistry and pathophysiology of diabetes. Proceedings of conference on pathophysiology and treatment of diabetes mellitus. 1990. Mol Cell Biochem. 1992, 109 (2): 97-204.
Surampudi PN, John-Kalarickal J, Fonseca VA: Emerging concepts in the pathophysiology of type 2 diabetes mellitus. Mt Sinai J Med. 2009, 76 (3): 216-26.
Johnson D: Selected pathophysiology of diabetes. Semin Perioper Nurs. 1998, 7 (3): 164-78.
Hirsch IB: The changing faces of diabetes. Prim Care. 2003, 30 (3): 499-510.
Guthrie RA, Guthrie DW: Pathophysiology of diabetes mellitus. Crit Care Nurs Q. , 27 (2): 113-25.
Felig P: Pathophysiology of diabetes mellitus. Med Clin North Am. 1971, 55 (4): 821-34.
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What is pathophysiology of diabetes?
Pathophysiology of diabetes refers to the study of the disordered physiological processes that lead to the development of diabetes mellitus.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, insulin action, or both.
The pathophysiology of diabetes involves the complex interplay of genetic, environmental, and lifestyle factors that contribute to the development of the disease.
In type 1 diabetes, the pathophysiology involves an autoimmune destruction of the insulin-producing beta cells in the pancreas, leading to a deficiency in insulin production.
This results in an inability to regulate blood glucose levels, leading to hyperglycemia (high blood sugar).
In type 2 diabetes, the pathophysiology is more complex and involves both insulin resistance and impaired insulin secretion.
Insulin resistance occurs when the body's cells do not respond properly to insulin, leading to an inability to effectively use glucose for energy.
This causes the pancreas to produce more insulin to try to overcome the resistance, but over time, the pancreas may not be able to keep up with the demand, leading to a decrease in insulin production.
Gestational diabetes, which occurs during pregnancy, is caused by hormonal changes that lead to insulin resistance.
The placenta produces hormones that can block the action of insulin, leading to an increase in blood glucose levels.
The pathophysiology of diabetes also involves the development of complications, such as damage to blood vessels, nerves, and organs, which can lead to serious health problems like heart disease, stroke, kidney disease, and vision loss.
Understanding the pathophysiology of diabetes is crucial for developing effective treatments and prevention strategies for this chronic disease.
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