Akciger rakynyň patofiziologiyasy akciger rakynyň ösüşi we ilerlemesinde bolýan adaty fiziologik prosesler we mehanizmlerdäki üýtgemeleri aňladýar.
Akciger raky akcigerdäki anormal öýjükleriň kontrolsuz ösüşinden we bölünmeginden döreýän murekkep kesellikdir.
Bu öýjükler tümör edip, bedeniň başga böleklerine ýaýrap, dürli alamatlara we agyrlaşmalar döredýär.
Akciger rakynyň patofiziologiyasy birnäçe faktorlary öz içine alýar, şol sanda genetik mutasiyalar, daşky şertler we ýaşaýş usuly saýlamalary.
Genetik mutasiyalar akciger öýjükleriniň DNA-synda bolup, öýjükleriň kontrolsuz ösüşine we bölünmegine eltýär.
Bu türlenmeler miras alnyp ýa-da edinilen bolup biler we olar çilim tüssesi, radon, asbest we howanyñ hapalanmagy ýaly rak döredýän zatlar sebäpli bolup biler.
Akciger raky iki esasy türe bölüp bolýar: kiçi öýjükli akciger raky (KÖAKR) we kiçi öýjükli däl akciger raky (KÖAKR). KÖAKR ýene üç ast türe bölünýär: adenokarsinoma, skvamöz öýjükli karsinoma we uly öýjükli karsinoma.
Bu tüssäniň rak görnüşleriniň patofiziologiyasy tapawutlanýar, çünki olar dürli genetik mutasyýalara we bejerişe dürli jogap berýärler.
Akciger rakynyň patofiziologiyasy rak öýjükleri we daş-töweregindäki ýüpler, şol sanda immün sistemasy arasyndaky täsirleşmegi hem öz içine alýar.
Kanser öýjükleri immun sistemasyndan gaçyp, olara çäklendirmezden ösmäge we ýaýramagyna ýol berýär.
Galyberse-de, rak mikroçerçegi rak öýjükleri üçin goldaýan bir şert döredip, rak ösüşini we metastazyny ilerilete biler.
Akciger rakynyň patofiziologiyasy murekkep we dinamik bir prosesdir we alymlar has täsirli bejergiler taýýarlamak we hassa netijelerini gowulandyrmak üçin esasy mehanizmleri gowy düşünmek üçin yzygiderli işleýärler.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
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What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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