What is pathophysiology of Lung cancer?

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肺癌嘅病理生理學係咩?

肺癌嘅病理生理學指喺肺癌嘅發育同進行中發生嘅正常生理過程同機制嘅變化.

肺癌係一種複雜嘅疾病 原因係肺部嘅異常細胞不受控制嘅生長同分裂

呢啲細胞可以形成腫瘤 然後擴散到身體其他部位 導致各種症狀同并發症

肺癌嘅病理生理學包括幾種因素,包括基因突變,環境因素,同埋生活方式.

肺細胞嘅DNA可能會發生基因突變, 導致細胞生長同分裂失控.

呢啲突變可以係遺傳性嘅,亦可以係經過暴露喺致癌物質,例如煙草煙,,石,同埋空氣污染所引起嘅.

肺癌可以分為兩種主要類型:小細胞肺癌 (SCLC) 同非小細胞肺癌 (NSCLC). NSCLC 再分為三種子類型:腺癌,細胞癌,大細胞癌.

呢類肺癌嘅病理生理學可能唔同,因為佢哋有唔同嘅基因突變,同埋對治療有唔同嘅反應.

肺癌嘅病理生理學亦包括癌細胞同周圍嘅組織,包括免疫系統之間嘅相互作用.

癌細胞可以逃避免疫系統 令佢哋可以無阻礙地生長同擴散

除此之外,腫瘤微環境可以為癌細胞提供支持性環境,促進腫瘤生長同轉移.

肺癌嘅病理生理係複雜而動態嘅過程 研究員不斷努力去更好地理解 肺癌嘅基本機制 嚟研發更有效嘅治療方法 同埋改善病人嘅治療結果

參考資料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.

Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.

Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.

Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .

Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .

Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.

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What is pathophysiology of lung cancer?

The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.

Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.

These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.

The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.

Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.

These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.

Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.

The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.

Cancer cells can evade the immune system, allowing them to grow and spread unchecked.

Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.

The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.

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