La fisiopatologjie dal tumôr al è il studi dai mecanisims e dai procès che a puartin al svilup e ae progression dal tumôr.
Il cancar al colon, cognossût ancje come cancar coloretâl, al è un tip di cancar che al scomence tal colon o intal ret, che a son tocs dal intestin grês.
Di solit al scomence come une cressite clamade polip, che cul timp e pues deventâ cancar.
La fisiopatologjie dal tumôr dal colon e tire dentri diviers fatôrs, come mutazions gjenetichis, infiamazions e fatôrs ambientâi.
Lis mutazions gjenetichis a puedin sucedi intal DNA des celulis dal colon, puartant a une cressite e division celulâr incontrolade.
Chestis mutazions a puedin jessi ereditaris o acuisidis, e a puedin influençâ diviers gjens coinvolts te cressite, la division e la riparazion des celulis.
L'infiammazion tal colon, che e pues jessi causade da malatiis come la malatie infiammatorie dal colon, e pues ancje aumentâ il risi di vê il cancar al colon.
La inflamazion croniche e pues puartâ al rilassi di sostancis chimichis che a promovin la cressite e la division celulâr, puartant potenzialmentri al svilup dal cancar.
Fatôrs ambientâi, come la diete, il mût di vivi e la esposizion a ciertis sostancis chimichis, a puedin ancje contribuî al svilup dal cancar al colon. ❚
Une diete ricje di cjars rosis e lavoradis, par esempli, e je stade colegade a un aument dal risi di tumôr al colon. ❚
Altris fatôrs, come l'obesitât, il fumâ e la mancjance di ativitât fisiche, a puedin ancje aumentâ il risi.
Une volte che il cancar al colon si è svilupât, al pues progredî a traviers di diviers stadis, dal cancar in stadi precoç che al è limitât al colon a stadis plui avanzadis dulà che il cancar si è slargjât a altris parts dal cuarp.
Lis celulis dal cancar a puedin invadisi dai tiessûts e dai orghins dongje, e a puedin ancje dilagjâsi traviers dal sisteme linfatic o dal flus sanguigni a sîts lontans, come il fiât o i polmons.
Il tratament pal cancar al colon al coinvolç di solit une cumbinazion di operazion, chemioterapie e radioterapie, a seconde de fase e posizion dal cancar.
La diagnosi precoce e il tratament a son fondamentâi par miorâ i risultâts, parcè che il cancar al colon al è spes curabil cuant che al ven cjatât intun stadi precoç.
Une visite periodiche, come la colonoscopie, e pues judâ a rilevâ il cancar al colon tai prins stadii, cuant che al è plui curabil.
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Tammali R, Ramana KV, Srivastava SK: Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett. 2007, 252 (2): 299-306.
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What is pathophysiology of colon cancer?
The pathophysiology of colon cancer refers to the underlying mechanisms and processes that lead to the development and progression of colon cancer.
Colon cancer, also known as colorectal cancer, is a type of cancer that begins in the colon or rectum, which are parts of the large intestine.
It typically starts as a growth called a polyp, which can develop into cancer over time.
The pathophysiology of colon cancer involves several factors, including genetic mutations, inflammation, and environmental factors.
Genetic mutations can occur in the DNA of colon cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can affect various genes involved in cell growth, division, and repair.
Inflammation in the colon, which can be caused by conditions such as inflammatory bowel disease, can also increase the risk of colon cancer.
Chronic inflammation can lead to the release of chemicals that promote cell growth and division, potentially leading to the development of cancer.
Environmental factors, such as diet, lifestyle, and exposure to certain chemicals, can also contribute to the development of colon cancer.
A diet high in red and processed meats, for example, has been linked to an increased risk of colon cancer.
Other factors, such as obesity, smoking, and lack of physical activity, can also increase the risk.
Once colon cancer develops, it can progress through several stages, from early-stage cancer that is confined to the colon to more advanced stages where the cancer has spread to other parts of the body.
The cancer cells can invade nearby tissues and organs, and may also spread through the lymphatic system or bloodstream to distant sites, such as the liver or lungs.
Treatment for colon cancer typically involves a combination of surgery, chemotherapy, and radiation therapy, depending on the stage and location of the cancer.
Early detection and treatment are key to improving outcomes, as colon cancer is often curable when caught in its early stages.
Regular screening, such as colonoscopy, can help detect colon cancer at its earliest stages, when it is most treatable.
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