Pathophysiology ya kankere ya mabele e kaya diphetogo tse di sa tlwaelegang mo ditsamaisong le mo dithulaganyong tse di tlwaelegileng tsa mmele tse di nnang teng fa go nna le kankere ya mabele le fa e ntse e etegela.
E akaretsa go ithuta ka mekgwa ya tlholego le ya dimolekhule e e dirang gore disele tsa kankere di gole di sa laolege le go anama mo dithishung tsa mabele.
Seno se akaretsa dilo tse di amanang le dijini, tsa tlholego le tikologo tse di dirang gore motho a nne le kankere ya mabele, a e oketse le go e etegela pele.
Dingwe tsa diphetogo tse dikgolo tsa pathophysiological mo kankere ya mabele di akaretsa:
1. Go fetoga ga dijini: Go fetoga ga dijini dingwe, tse di jaaka BRCA1 le BRCA2, go ka oketsa kotsi ya go tshwarwa ke kankere ya mabele.
Diphetogo tseno di ka nna tsa bo di tswa mo batsading kgotsa di ka nna tsa nna gone fa motho a sa ntse a tshela.
2. Go sa lekalekane ga dihoromone: Dihoromone, segolobogolo estrogen, di ka nna le seabe mo go direng gore motho a nne le kankere ya mabele le gore e gole.
Go sa lekalekane ga dihoromone kana go nna le estrogen e ntsi go ka oketsa kotsi ya go tshwarwa ke kankere ya mabele.
3. Go ruruga: Go ruruga go go sa foleng ga dithishu tsa mabele go ka dira gore motho a nne le kankere ya mabele ka go dira gore disele tsa kankere di gole le go tshela.
4. Tikologo e e dikologileng tlhagala: Tikologo e e dikologileng tlhagala, go akaretsa le dikarolo tse di kwa ntle ga sele, disele tse di lwantshang malwetse le ditshika tsa madi, e ka tlhotlheletsa go gola le go anama ga kankere ya mabele.
5. Go anama ga kankere: Kankere ya mabele e ka anama go ya kwa dikarolong tse dingwe tsa mmele ka thulaganyo ya lymphatic kana ka madi, e dira gore go nne le ditlhagala tse dingwe mo dirweng tse di kgakala.
Go tlhaloganya pathophysiology ya kankere ya mabele go botlhokwa thata gore go nne le mekgwa e e molemo ya go thibela kankere, go e lemoga ka bonako le go e alafa.
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Paliwal SR, Paliwal R, Agrawal GP, Vyas SP: Liposomal nanomedicine for breast cancer therapy. Nanomedicine (Lond). 2011, 6 (6): 1085-100.
Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
Wei H, Wang H, Ji Q, Sun J, Tao L, Zhou X: NRBP1 is downregulated in breast cancer and NRBP1 overexpression inhibits cancer cell proliferation through Wnt/β-catenin signaling pathway. Onco Targets Ther. 2015, 8 (): 3721-30.
Eden JA: Human breast cancer stem cells and sex hormones--a narrative review. Menopause. 2010, 17 (4): 801-10.
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA: Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res. 2008, 14 (24): 8010-8.
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What is pathophysiology of breast cancer?
Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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