Pathophysiology ya kankere ya makgwafo e kaya diphetogo mo ditsamaisong le mo dithulaganyong tse di tlwaelegileng tsa mmele tse di nnang teng fa go nna le kankere ya makgwafo le fa e ntse e etegela.
Kankere ya makgwafo ke bolwetse jo bo raraaneng jo bo bakwang ke go gola le go ikgaoganya ga disele tse di sa tlwaelegang mo makgwafong.
Disele tseno di ka dira ditlhagala mme tsa anama go ya kwa dikarolong tse dingwe tsa mmele, mme tsa baka matshwao le mathata a a farologaneng.
Pathophysiology ya kankere ya makgwafo e akaretsa dilo di le mmalwa, go akaretsa le go fetoga ga dijini, dilo tse di amanang le tikologo le tsela e motho a tshelang ka yone.
Go ka nna le diphetogo tsa dijini mo DNA ya disele tsa makgwafo, tse di ka dirang gore disele di gole di bo di kgaogane ka tsela e e sa laolesegeng.
Diphetogo tseno di ka nna tsa bo di gotsitswe mo batsading kgotsa tsa nna gone ka ntlha ya go bo motho a godile, mme di ka nna tsa bakwa ke go nna mo lefelong le le nang le dilo tse di bakang kankere, tse di jaaka mosi wa motsoko, radon, asbestos le kgotlelo ya moya.
Kankere ya makgwafo e ka aroganngwa ka mefuta e mebedi e megolo: small cell lung cancer (SCLC) le non-small cell lung cancer (NSCLC). NSCLC e kgaogantswe gape ka mefuta e meraro: adenocarcinoma, squamous cell carcinoma, le large cell carcinoma.
Pathophysiology ya mefuta eno ya kankere ya makgwafo e ka farologana, ka gonne e na le diphetogo tse di farologaneng tsa dijini mme e tsibogela kalafi ka tsela e e farologaneng.
Pathophysiology ya kankere ya makgwafo gape e akaretsa go dirisana ga disele tsa kankere le dithishu tse di e dikologileng, go akaretsa le thulaganyo ya mmele ya go lwantsha malwetse.
Disele tsa kankere di kgona go tila thulaganyo ya mmele ya go lwantsha malwetse, mme seo se dira gore di gole di bo di aname di sa thibelwe.
Mo godimo ga moo, tikologo e nnye ya tlhagala e ka dira gore tlhagala e gole le go anama ka go dira gore disele tsa kankere di nne le tikologo e e siameng.
Pathophysiology ya kankere ya makgwafo ke thulaganyo e e raraaneng le e e maatla, mme babatlisisi ba dira ka metlha go tlhaloganya botoka mekgwa e e mo teng ga yone gore ba kgone go dira kalafi e e nang le matswela le go tokafatsa seemo sa balwetse.
Li Z, Qian Y, Li W, Liu L, Yu L, Liu X, Wu G, Wang Y, Luo W, Fang F, Liu Y, Song F, Cai Z, Chen W, Huang W: Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020, 23 (8): 101411.
Nurwidya F, Syahruddin E, Yunus F: Pain management in lung cancer. Adv Respir Med. 2016, 84 (6): 331-336.
Khan KA, Kennedy MP, Moore E, Crush L, Prendeville S, Maher MM, Burke L, Henry MT: Radiological characteristics, histological features and clinical outcomes of lung cancer patients with coexistent idiopathic pulmonary fibrosis. Lung. 2015, 193 (1): 71-7.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A: Extracellular Vesicle (EVs) Associated Non-Coding RNAs in Lung Cancer and Therapeutics. Int J Mol Sci. 2022, 23 (21): .
Lee D, Kim Y, Chung C: Scientific Validation and Clinical Application of Lung Cancer Organoids. Cells. 2021, 10 (11): .
Mucchietto V, Crespi A, Fasoli F, Clementi F, Gotti C: Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Curr Pharm Des. 2016, 22 (14): 2160-9.
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['Fa o sa akaretse tshedimosetso yotlhe e e fa godimo e ka nna ya diegisa go sekasekwa ga ngongorego ya gago.']
['Go Ikgolaganya']
['Tsweetswee re romelele imeile ka potso/kgakololo epe fela.']
What is pathophysiology of lung cancer?
The pathophysiology of lung cancer refers to the changes in the normal physiological processes and mechanisms that occur in the development and progression of lung cancer.
Lung cancer is a complex disease that arises from the uncontrolled growth and division of abnormal cells in the lungs.
These cells can form tumors and spread to other parts of the body, leading to various symptoms and complications.
The pathophysiology of lung cancer involves several factors, including genetic mutations, environmental factors, and lifestyle choices.
Genetic mutations can occur in the DNA of lung cells, leading to uncontrolled cell growth and division.
These mutations can be inherited or acquired, and they can be caused by exposure to carcinogens, such as tobacco smoke, radon, asbestos, and air pollution.
Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is further divided into three subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
The pathophysiology of these types of lung cancer can differ, as they have different genetic mutations and respond differently to treatment.
The pathophysiology of lung cancer also involves the interaction between cancer cells and the surrounding tissue, including the immune system.
Cancer cells can evade the immune system, allowing them to grow and spread unchecked.
Additionally, the tumor microenvironment can promote tumor growth and metastasis by providing a supportive environment for cancer cells.
The pathophysiology of lung cancer is a complex and dynamic process, and researchers are continuously working to better understand the underlying mechanisms to develop more effective treatments and improve patient outcomes.
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