How is Prostate cancer diagnosed?

['Yingisela tluka leri']

Xana khensa ya nhlaribya ya vununa yi voniwa njhani?

Khensa ya nhlaribya ya vununa yi voniwa hi ku tirhisa tindlela to hambana-hambana to kambela, leti nga ha katsaka:

1. Digital Rectal Exam (DRE): Dokodela u nghenisa ritiho leri nga ni xisibi xa mavoko ni mafurha eka thundhela leswaku a kambela nhlaribya ya vununa loko yi nga ri kahle.

2. Nkambisiso wa Prostate-Specific Antigen (PSA): I nkambisiso wa ngati lowu kombisaka mpimo wa PSA, ku nga phrotheyini leyi humesiwaka hi nhlaribya ya vununa.

Loko mpimo wa PSA wu tlakukile swi nga ha kombisa leswaku u ni khensa ya nhlaribya ya vununa.

3. Transrectal Ultrasound (TRUS): Ku nghenisiwa nchumu lowutsongo eka thumbu leswaku ku tekiwa xifaniso xa nhlaribya ya vununa hi ku tirhisa magandlati ya mpfumawulo.

Leswi swi nga pfuna ku vona loko ku ri ni leswi nga fambiki kahle eka nhlaribya ya vununa.

4. Ku teka tisele ta tshumba: Ku tekiwa tisele letitsongo ta nhlaribya ya vununa kutani ti kambisisiwa hi makhiroskopu ku vona loko ti ri ni tisele ta khensa.

Leyi hi yona ntsena ndlela leyi tiyeke yo vona khensa ya nhlaribya ya vununa.

5. Magnetic Resonance Imaging (MRI): MRI ya nhlaribya ya vununa yi nga pfuna ku vona loko yi nga tirhi kahle kutani yi kongomisa endlelo ro yi kambela.

6. Ku Kambisisa Xitekela: Madokodela man'wana ma nga ha tirhisa ku kamberiwa ka xitekela leswaku ma kota ku vona loko khensa yi ri ni khombo ni ku pfuna ku endla swiboho swa vutshunguri.

7. Ku Kambisisa Marhambu: Ku nga ha endliwa ku kamberiwa ka marhambu ku vona loko khensa yi hangalake yi ya fika emarhameni.

8. Xitirhisiwa xa Computed Tomography (CT) Scan: Xitirhisiwa xa CT scan xi nga ha tirhisiwa ku vona loko khensa yi hangalake ni swirho swin'wana kumbe tinyama.

I swa nkoka ku xiya leswaku a hi vavanuna hinkwavo lava nga ni mpimo wa PSA lowu tlakukaka kumbe DRE leyi nga riki kahle lava nga ni khensa ya nhlaribya ya vununa, naswona a hi khensa hinkwayo ya nhlaribya ya vununa leyi nga vangaka mpimo wa PSA lowu tlakukaka.

Hikwalaho, ku laveka leswaku ku endliwa biopsy leswaku ku tiyisekisiwa leswaku vuvabyi lebyi i bya xiviri.

Ku engetela kwalaho, xiboho xa ku endla nkambisiso wa tisele xi endliwa endzhaku ko kambisisa vuyelo bya minkambisiso leyi ni swilo leswi nga vangaka khombo ni leswi munhu a swi tsakelaka.

['Tinhlamuselo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Saldova R, Fan Y, Fitzpatrick JM, Watson RW, Rudd PM: Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia. Glycobiology. 2011, 21 (2): 195-205.

Marenco J, Kasivisvanathan V, Emberton M: New standards in prostate biopsy. Arch Esp Urol. 2019, 72 (2): 142-149.

Moradi M, Mousavi P, Abolmaesumi P: Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review. Ultrasound Med Biol. 2007, 33 (7): 1010-28.

Cuperlovic-Culf M, Belacel N, Davey M, Ouellette RJ: Multi-gene biomarker panel for reference free prostate cancer diagnosis: determination and independent validation. Biomarkers. 2010, 15 (8): 693-706.

McGrath SE, Michael A, Morgan R, Pandha H: EN2: a novel prostate cancer biomarker. Biomark Med. 2013, 7 (6): 893-901.

An Y, Chang W, Wang W, Wu H, Pu K, Wu A, Qin Z, Tao Y, Yue Z, Wang P, Wang Z: A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn2+ in healthy versus cancerous cells. J Adv Res. 2020, 24 (): 363-370.

[Consensus of Chinese experts on the application of molecular imaging targeting prostate specific membrane antigen in prostate cancer patients]. Zhonghua Wai Ke Za Zhi. 2018, 56 (2): 91-94.

Zhong WD, He HC, Bi XC, Ou RB, Jiang SA, Liu LS: cDNA macroarray for analysis of gene expression profiles in prostate cancer. Chin Med J (Engl). 2006, 119 (7): 570-3.

['Xihlambanyo xa vutihlamuleri: swa vutshunguri']

['Website leyi yi endleriwe ku dyondzisa ni ku nyika rungula ntsena naswona a yi nyiki switsundzuxo swa vutshunguri kumbe mintirho ya vativi va swa vutshunguri.']

['Rungula leri nyikeriweke a ri fanelanga ri tirhisiwa ku kambela kumbe ku tshungula xiphiqo xa rihanyo kumbe vuvabyi, naswona lava lavaka xitsundzuxo xa vutshunguri va fanele va vonana ni dokodela la nga ni mpfumelelo.']

['Xiya leswaku ndlela leyi ti-neural net ti hlamulaka swivutiso ha yona a yi pakanisi ngopfu loko ku vulavuriwa hi tinomboro, to tanihi nhlayo ya vanhu lava khomiweke hi vuvabyi byo karhi.']

["Minkarhi hinkwayo kombela xitsundzuxo eka dokodela wa wena kumbe eka muongori la fanelekaka malunghana ni xiyimo xa rihanyo ra wena. U nga tshuki u honisa xitsundzuxo xa dokodela kumbe u hlwela ku xi lava hikwalaho ka leswi u swi hlayeke eka website leyi. Loko u ehleketa leswaku u le xiyin'weni xa xihatla xa rihanyo, bela riqingho eka 911 kumbe u ya ekamareni ra xihatla leri nga ekusuhi na wena hi ku hatlisa. A ku na vuxaka bya dokodela ni muvabyi lebyi tumbuluxiweke hi website leyi kumbe ku tirhisiwa ka yona. BioMedLib kumbe vatirhi va yona, kumbe un'wana ni un'wana la hoxaka xandla eka website leyi, a nga endli switiyisekiso, leswi nga erivaleni kumbe leswi nga erivaleni, malunghana ni rungula leri nga laha kumbe ku tirhisiwa ka rona."]

['Ku ala ku byarha vutihlamuleri: mfanelo yo tsala']

['Nawu wa Digital Millennium Copyright Act wa 1998, 17 U.S.C. § 512 (DMCA) wu nyika tindlela ta ku tihlanganisa na vini va timfanelo ta vuhleri lava va tshembaka leswaku swilo leswi humelelaka eka Internet swi tlula timfanelo ta vona ehansi ka nawu wa vuhleri wa U.S.']

['Loko u tshemba leswaku rungula kumbe swilo leswi kumekaka eka website ya hina kumbe eka mintirho ya hina swi tlula mfanelo ya wena yo endla swilo, wena (kumbe muyimeri wa wena) u nga hi rhumela xitiviso u kombela leswaku rungula kumbe swilo leswi swi susiwa kumbe swi siveriwa.']

['Switiviso swi fanele ku rhumeriwa hi ku tsala hi imeyili (languta eka xiyenge xa "Vuxaka" eka adirese ya imeyili).']

["DMCA yi lava leswaku xitiviso xa wena xa ku tlula nawu wa mfanelo ya ku tsala xi katsa mahungu lawa landzelaka: (1) nhlamuselo ya ntirho lowu nga na mfanelo ya ku tsala lowu ku vuriwaka leswaku wu tluriwile; (2) nhlamuselo ya leswi ku vuriwaka leswaku swi tlula nawu wa ku tsala ni mahungu lama ringaneke ku hi pfumelela ku kuma leswi nga endzeni; (3) mahungu ya ku tihlanganisa na wena, ku katsa ni adirese ya wena, nomboro ya riqingho na adirese ya imeyili; (4) xitiviso xa wena xa leswaku u ni ripfumelo ra leswaku leswi nga endzeni hi ndlela leyi ku vilelaka ha yona a swi pfumeleriwanga hi n'wini wa mfanelo ya ku tsala, kumbe muyimeri wa yena, kumbe hi ku tirha ka nawu wihi na wihi; "]

['(5) xitiyisiso xa wena, lexi sayiniweke ehansi ka nxupulo wa ku hemba, xa leswaku mahungu lama nga eka xitiviso i ntiyiso ni leswaku u na matimba yo tirhisa timfanelo ta vuqambi leti ku vuriwaka leswaku ti tluriwile;']

["na (6) ku sayina ka xiviri kumbe ka elektroniki ka n'wini wa mfanelo ya vuqambi kumbe munhu la pfumeleriweke ku endla hi vito ra n'wini wa mfanelo ya vuqambi. "]

['Loko u nga nghenisi vuxokoxoko hinkwabyo lebyi nga laha henhla swi nga endla leswaku ku tirhana ni xivilelo xa wena swi hlwela.']

['Ku Tihlanganisa']

['Hi kombela u hi rhumela imeyili hi xivutiso/xiringanyeto xihi na xihi.']

How is prostate cancer diagnosed?

Prostate cancer is diagnosed through a combination of tests and procedures, which may include:

1. Digital Rectal Exam (DRE): A doctor inserts a gloved, lubricated finger into the rectum to feel the prostate for any abnormalities.

2. Prostate-Specific Antigen (PSA) Test: This is a blood test that measures the level of PSA, a protein produced by the prostate gland.

Elevated PSA levels may indicate the presence of prostate cancer.

3. Transrectal Ultrasound (TRUS): A small probe is inserted into the rectum to create an image of the prostate using sound waves.

This can help identify any abnormalities in the prostate gland.

4. Biopsy: A small sample of prostate tissue is removed and examined under a microscope for the presence of cancer cells.

This is the only definitive way to diagnose prostate cancer.

5. Magnetic Resonance Imaging (MRI): An MRI scan of the prostate can help identify any abnormalities and guide the biopsy procedure.

6. Genomic Testing: Some doctors may use genomic tests to help determine the aggressiveness of the cancer and guide treatment decisions.

7. Bone Scan: A bone scan may be performed to check if the cancer has spread to the bones.

8. Computed Tomography (CT) Scan: A CT scan may be used to check if the cancer has spread to other organs or tissues.

It is important to note that not all men with elevated PSA levels or abnormal DRE results will have prostate cancer, and not all prostate cancers will cause elevated PSA levels.

Therefore, a biopsy is necessary to confirm the diagnosis.

Additionally, the decision to undergo a biopsy is made after considering the results of these tests and the individual's risk factors and preferences.

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