What causes Colon cancer?

Yintoni ebangela umhlaza womlomo?

Umhlaza womgudu, okwabizwa ngokuba ngumhlaza womgudu, ubangelwa kukwanda okungalawulekiyo kweeseli ezingaqhelekanga kumgudu okanye kumgudu ongena ngaphakathi.

Isizathu esichanekileyo somhlaza womqala asiziwa, kodwa kukho izinto ezininzi ezinokunyusa umngcipheko wokuphuhliswa kwesi sifo.

Ezi ziquka:

1. Ubudala: Umngcipheko wokuba nomhlaza womqala unyuka ngokweminyaka, yaye ubukhulu becala uba kubantu abaneminyaka engaphezu kwama-50.

2. Imbali yentsapho: Ukuba wena okanye intsapho yakho inembali yomhlaza wamathumbu okanye ipolipo kwandisa amathuba okuba nesi sifo.

3. Iimpawu ezizuzwe njengelifa: Iimpawu ezithile ezizuzwe njengelifa, ezinjengefamilial adenomatous polyposis (FAP) nomhlaza womqala ongenayo i-polyposis (HNPCC), zinokunyusa ingozi yokuba nomhlaza womqala.

4. Indlela yokuphila: Ukutya inyama ebomvu, ukutyeba kakhulu, ukutshaya nokusela kakhulu kunokubangela umhlaza womqala.

5. Isifo sokuvuvukala kwamathumbu: Izifo zokuvuvukala kwamathumbu ezihlala ixesha elide, ezinjengeulcerative colitis nesifo sikaCrohn, zinokunyusa ingozi yokuba nomhlaza wamathumbu.

6. Isifo seswekile sohlobo 2: Abantu abanesifo seswekile sohlobo 2 basengozini enkulu yokuba nomhlaza womqala.

7. Unyango ngemitha: Unyango ngemitha xa kukho ezinye iintlobo zomhlaza esiswini lunokubangela ukuba umntu abe nomhlaza womqala.

8. Uhlanga: Abantu baseAfrika nabaseMerika basengozini enkulu yokuba nomhlaza womqala kunabanye abantu bezinye iintlanga.

Kubalulekile ukuqaphela ukuba ukuba nomnye okanye ngaphezulu kwezi zinto zenza umngcipheko akuthethi ukuba umntu uza kuba nomhlaza womqala, kwaye abanye abantu abanomhlaza womqala basenokungabinayo imiba eyaziwayo yomngcipheko.

Ukuxilongwa rhoqo nokufunyaniswa kwangethuba komhlaza womqala kunokunceda ukuthintela okanye ukuwufumana kwangethuba xa unokunyangwa.

['Iimbekiselo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

McWhirter JE, Todd LE, Hoffman-Goetz L: Beliefs about causes of colon cancer by English-as-a-Second-Language Chinese immigrant women to Canada. J Cancer Educ. 2011, 26 (4): 734-9.

Gamble JF: Asbestos and colon cancer: a weight-of-the-evidence review. Environ Health Perspect. 1994, 102 (12): 1038-50.

Ashish S, Raj M: Importance of Early Next-Generation Sequencing in Microsatellite Unstable Colon Cancer With a High Tumor Mutation Burden. Cureus. 2022, 14 (3): e22894.

Xu W, Zhang Y, Chen L, Qiu F, Zhang B, Wu L, Peng Z, Tang H: Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget. 2017, 8 (42): 71954-71964.

Wang J, Wu HF, Shen W, Xu DY, Ruan TY, Tao GQ, Lu PH: SRPK2 promotes the growth and migration of the colon cancer cells. Gene. 2016, 586 (1): 41-7.

Taketo MM, Edelmann W: Mouse models of colon cancer. Gastroenterology. 2009, 136 (3): 780-98.

Slattery ML, Kerber RA: The impact of family history of colon cancer on survival after diagnosis with colon cancer. Int J Epidemiol. 1995, 24 (5): 888-96.

['Ukuzikhusela: unyango']

['Le webhsayithi yenzelwe ukufundisa nokunika inkcazelo kuphela yaye ayibonisi ukuba inikela amacebiso ezonyango okanye iinkonzo zobungcali.']

['Inkcazelo enikelweyo ayifanele isetyenziselwe ukuxilonga okanye ukunyanga ingxaki yempilo okanye isifo, yaye abo bafuna icebiso lonyango lobuqu bafanele babonane nogqirha onelayisensi.']

['Nceda uqaphele ukuba inethiwekhi ye-neural eyenza iimpendulo kwimibuzo, ayichanekanga xa kufikwa kumxholo wenani. Umzekelo, inani labantu abafunyaniswe benesifo esithile.']

['Soloko ucela icebiso kugqirha wakho okanye komnye umboneleli wezempilo ofanelekileyo malunga nemeko yakho yezonyango. Ungaze ungayihoyi ingcebiso yezonyango okanye ulibazise ukufuna ngenxa yento oyifunde kule webhusayithi. Ukuba ucinga ukuba unengxaki yezonyango, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko. Akukho buhlobo bukagqirha nomguli obudalwa yile webhusayithi okanye ukusetyenziswa kwayo. I-BioMedLib okanye abasebenzi bayo, okanye nabani na onegalelo kule webhusayithi, abenzi zimelo, ngokucacileyo okanye ngokungangqalanga, ngokubhekisele kulwazi olunikezwe apha okanye ekusetyenzisweni kwalo.']

['Ukuzikhulula: ilungelo lokushicilela']

['Umthetho we-Digital Millennium Copyright ka-1998, 17 U.S.C. § 512 (i-DMCA) ubonelela ngeendlela zokubhena kubanini bamalungelo obunini abakholelwa ukuba izinto ezibonakala kwi-Intanethi ziphula amalungelo abo phantsi komthetho welungelo lokushicilela wase-US. ']

['Ukuba ukholelwa ukuba kukho umxholo okanye izinto ezenziwe zafumaneka kwi-website yethu okanye iinkonzo eziphula ilungelo lakho lokushicilela, wena (okanye iarhente yakho) ungathumela isaziso esicela ukuba umxholo okanye izinto zisuswe, okanye ukufikelela kuzo kuvalwe. ']

['Izaziso kufuneka zithunyelwe ngokubhaliweyo nge-imeyile (jonga kwicandelo elithi "Qhagamshelana" ukuze ufumane idilesi ye-imeyile).']

['I-DMCA ifuna ukuba isaziso sakho sokutyholwa ngokophula ilungelo lokushicilela siquke ezi nkcukacha zilandelayo: (1) inkcazelo yomsebenzi onelungelo lokushicilela ongundaba-mlonyeni wokutyholwa ngokophula; (2) inkcazelo yomxholo otyholwa ngokophula kunye nolwazi olwaneleyo ukusivumela ukuba sifumane umxholo; (3) iinkcukacha zokuqhagamshelana nawe, kuquka idilesi yakho, inombolo yomnxeba nedilesi ye-imeyile; (4) ingxelo yakho yokuba unokholo olulungileyo lokuba umxholo ngendlela ekhalazwa ngayo awugunyaziswanga ngumnini welungelo lokushicilela, okanye iarhente yakhe, okanye ngokusebenza kwawo nawuphi na umthetho; ']

['(5) ingxelo yakho, esayinwe phantsi kwesohlwayo sobuxoki, yokuba ulwazi olukwisibhengezo luchanekile kwaye unegunya lokunyanzelisa amalungelo okushicilela ekuthiwa aphulwe;']

['kwaye (6) utyikityo lomzimba okanye lwe-elektroniki lomnini welungelo lokushicilela okanye lomntu ogunyazisiweyo ukuba enze egameni lomnini welungelo lokushicilela. ']

['Ukungabandakanyi lonke ulwazi olungentla kungakhokelela ekulibaziseni ukuphathwa kwesikhalazo sakho.']

['Unxibelelwano']

['Nceda usithumelele i-imeyile ngayo nayiphi na imibuzo / iingcebiso.']

What causes colon cancer?

Colon cancer, also known as colorectal cancer, is caused by the uncontrolled growth of abnormal cells in the colon or rectum.

The exact cause of colon cancer is not known, but several factors can increase the risk of developing the disease.

These include:

1. Age: The risk of colon cancer increases with age, with most cases occurring in people over the age of 50.

2. Family history: A personal or family history of colon cancer or polyps increases the risk of developing the disease.

3. Inherited syndromes: Certain inherited genetic syndromes, such as familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), can increase the risk of colon cancer.

4. Lifestyle factors: A diet high in red and processed meats, obesity, smoking, and excessive alcohol consumption can increase the risk of colon cancer.

5. Inflammatory bowel disease: Long-term inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, can increase the risk of colon cancer.

6. Type 2 diabetes: People with type 2 diabetes have an increased risk of developing colon cancer.

7. Radiation therapy: Radiation therapy for other cancers in the abdomen can increase the risk of colon cancer.

8. Race: African Americans have a higher risk of developing colon cancer than other races.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop colon cancer, and some people who develop colon cancer may not have any known risk factors.

Regular screening and early detection can help prevent colon cancer or detect it at an early stage when it is most treatable.

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