乳腺癌嘅病理生理學指喺乳腺癌嘅發育同進行中發生嘅正常生理過程同機制嘅異常變化.
佢包括研究 導致癌細胞喺乳腺組織中無管制生長同擴散嘅基本生物同分子機制
其中包括基因,表观遗传和环境因素 促进乳腺癌的发作,促进和进展.
乳腺癌嘅主要病理生理變化包括:
1. 基因突變:某些基因嘅突變,例如 BRCA1 同 BRCA2, 可以增加患乳腺癌嘅風險.
呢啲突變可以喺一個人一生中傳承或者獲得.
2. 荷爾蒙失衡: 荷爾蒙,特別係雌激素, 可能對乳腺癌嘅發育同生長起作用.
荷爾蒙水平失衡或者過度暴露於雌激素可以增加乳腺癌嘅風險.
3. 炎症: 乳腺組織嘅慢性炎症 可以促進乳腺癌嘅生長同存活
4. 腫瘤微環境: 腫瘤周圍嘅環境,包括細胞外基質,免疫細胞同血管, 都可以影響乳腺癌嘅生長同擴散.
5. 转移: 乳腺癌可以通过淋巴系统或血流扩散到身体的其他部位, 导致在遥远的器官中形成二次
了解乳腺癌嘅病理生理學 對制定有效嘅預防,早期發現同治療策略係好重要嘅
PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html
RefinedWeb https://arxiv.org/abs/2306.01116
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Rauch GM, Adrada BE: Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation. Magn Reson Imaging Clin N Am. 2018, 26 (2): 273-280.
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Pathophysiology of breast cancer refers to the abnormal changes in the normal physiological processes and mechanisms that occur in the development and progression of breast cancer.
It involves the study of the underlying biological and molecular mechanisms that lead to the uncontrolled growth and spread of cancer cells in the breast tissue.
This includes the genetic, epigenetic, and environmental factors that contribute to the initiation, promotion, and progression of breast cancer.
Some of the key pathophysiological changes in breast cancer include:
1. Genetic mutations: Mutations in certain genes, such as BRCA1 and BRCA2, can increase the risk of developing breast cancer.
These mutations can be inherited or acquired during a person's lifetime.
2. Hormonal imbalances: Hormones, particularly estrogen, can play a role in the development and growth of breast cancer.
An imbalance in hormone levels or exposure to excess estrogen can increase the risk of breast cancer.
3. Inflammation: Chronic inflammation in the breast tissue can contribute to the development of breast cancer by promoting the growth and survival of cancer cells.
4. Tumor microenvironment: The environment surrounding the tumor, including the extracellular matrix, immune cells, and blood vessels, can influence the growth and spread of breast cancer.
5. Metastasis: Breast cancer can spread to other parts of the body through the lymphatic system or bloodstream, leading to the formation of secondary tumors in distant organs.
Understanding the pathophysiology of breast cancer is crucial for developing effective prevention, early detection, and treatment strategies.
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