How is Prostate cancer diagnosed?

['Phulaphula eli phepha']

Uxilongwa njani umhlaza wedlala lesinyi?

Umhlaza wedlala lesinyi ufumaniseka ngokudibanisa iimvavanyo neenkqubo, ezinokuquka:

1. Ukuxilongwa Kwesibeleko Ngesixhobo Esisetyenziswa Ezandleni (DRE): Ugqirha ufaka umnwe ogqunywe ngegloves, nonamafutha kwilungu langasese ukuze azive ukuba kukho into engaqhelekanga kusini na.

Uvavanyo lwe-PSA (Prostate-Specific Antigen): Olu luvavanyo lwegazi olujonga umlinganiselo we-PSA, iprotini eveliswa yidlala lesinyi.

Amanqanaba aphakamileyo e-PSA asenokubonisa ukuba kukho umhlaza wedlala lesinyi.

3. I-Transrectal Ultrasound (TRUS): Kufakwa isixhobo esincinane kwi-rectum ukuze kwenziwe umfanekiso weprostate kusetyenziswa amaza esandi.

Oku kunokukunceda ubone nayiphi na into engaqhelekanga kwiprostate gland.

4. Ukwenziwa kwezinto eziphilayo: Kuthatyathwa isampulu encinane yesifo seprostate ize ihlolwe ngemikroskopu ukuze kubonwe ukuba azikho na iiseli ezinomhlaza.

Le kuphela kwendlela eqinisekileyo yokufumanisa umhlaza wedlala lesinyi.

5. IMagnetic Resonance Imaging (MRI): Ukuxilongwa kweprostate ngeMRI kunokukunceda ubone nantoni na engaqhelekanga uze ukwazi ukuxilonga.

6. Uvavanyo LweDNA: Abanye oogqirha basenokusebenzisa uvavanyo lweDNA ukuze babone ukuba umhlaza ukhula kangakanani baze benze izigqibo zonyango.

7. Ukuxilongwa kwamathambo: Kunokuxilongwa amathambo ukuze kubonwe enoba umhlaza uye wanwenwela na emathanjeni.

8. IComputed Tomography (CT) Scan: ICT scan inokusetyenziswa ukuhlola enoba umhlaza uye wanwenwela kwamanye amalungu omzimba okanye kwizihlunu kusini na.

Kubalulekile ukuqaphela ukuba ayingabo bonke abantu abanamanqanaba e-PSA aphakamileyo okanye iziphumo ze-DRE ezingaqhelekanga abaya kuba nomhlaza wedlala lesinyi, kwaye ayingabo bonke abantu abanomhlaza wedlala lesinyi abaya kuba namanqanaba e-PSA aphakamileyo.

Ngoko ke kufuneka kwenziwe uvavanyo lwegazi ukuze kuqinisekiswe ukuba ifunyenwe.

Ukongezelela, isigqibo sokwenza uvavanyo lwebiopsy senziwa emva kokuqwalasela iziphumo zolu vavanyo nezinto ezibangela ukuba umntu abe sesichengeni nezinto azithandayo.

['Iimbekiselo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Saldova R, Fan Y, Fitzpatrick JM, Watson RW, Rudd PM: Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia. Glycobiology. 2011, 21 (2): 195-205.

Marenco J, Kasivisvanathan V, Emberton M: New standards in prostate biopsy. Arch Esp Urol. 2019, 72 (2): 142-149.

Moradi M, Mousavi P, Abolmaesumi P: Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review. Ultrasound Med Biol. 2007, 33 (7): 1010-28.

Cuperlovic-Culf M, Belacel N, Davey M, Ouellette RJ: Multi-gene biomarker panel for reference free prostate cancer diagnosis: determination and independent validation. Biomarkers. 2010, 15 (8): 693-706.

McGrath SE, Michael A, Morgan R, Pandha H: EN2: a novel prostate cancer biomarker. Biomark Med. 2013, 7 (6): 893-901.

An Y, Chang W, Wang W, Wu H, Pu K, Wu A, Qin Z, Tao Y, Yue Z, Wang P, Wang Z: A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn2+ in healthy versus cancerous cells. J Adv Res. 2020, 24 (): 363-370.

[Consensus of Chinese experts on the application of molecular imaging targeting prostate specific membrane antigen in prostate cancer patients]. Zhonghua Wai Ke Za Zhi. 2018, 56 (2): 91-94.

Zhong WD, He HC, Bi XC, Ou RB, Jiang SA, Liu LS: cDNA macroarray for analysis of gene expression profiles in prostate cancer. Chin Med J (Engl). 2006, 119 (7): 570-3.

['Ukuzikhusela: unyango']

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['Soloko ucela icebiso kugqirha wakho okanye komnye umboneleli wezempilo ofanelekileyo malunga nemeko yakho yezonyango. Ungaze ungayihoyi ingcebiso yezonyango okanye ulibazise ukufuna ngenxa yento oyifunde kule webhusayithi. Ukuba ucinga ukuba unengxaki yezonyango, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko. Akukho buhlobo bukagqirha nomguli obudalwa yile webhusayithi okanye ukusetyenziswa kwayo. I-BioMedLib okanye abasebenzi bayo, okanye nabani na onegalelo kule webhusayithi, abenzi zimelo, ngokucacileyo okanye ngokungangqalanga, ngokubhekisele kulwazi olunikezwe apha okanye ekusetyenzisweni kwalo.']

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['Izaziso kufuneka zithunyelwe ngokubhaliweyo nge-imeyile (jonga kwicandelo elithi "Qhagamshelana" ukuze ufumane idilesi ye-imeyile).']

['I-DMCA ifuna ukuba isaziso sakho sokutyholwa ngokophula ilungelo lokushicilela siquke ezi nkcukacha zilandelayo: (1) inkcazelo yomsebenzi onelungelo lokushicilela ongundaba-mlonyeni wokutyholwa ngokophula; (2) inkcazelo yomxholo otyholwa ngokophula kunye nolwazi olwaneleyo ukusivumela ukuba sifumane umxholo; (3) iinkcukacha zokuqhagamshelana nawe, kuquka idilesi yakho, inombolo yomnxeba nedilesi ye-imeyile; (4) ingxelo yakho yokuba unokholo olulungileyo lokuba umxholo ngendlela ekhalazwa ngayo awugunyaziswanga ngumnini welungelo lokushicilela, okanye iarhente yakhe, okanye ngokusebenza kwawo nawuphi na umthetho; ']

['(5) ingxelo yakho, esayinwe phantsi kwesohlwayo sobuxoki, yokuba ulwazi olukwisibhengezo luchanekile kwaye unegunya lokunyanzelisa amalungelo okushicilela ekuthiwa aphulwe;']

['kwaye (6) utyikityo lomzimba okanye lwe-elektroniki lomnini welungelo lokushicilela okanye lomntu ogunyazisiweyo ukuba enze egameni lomnini welungelo lokushicilela. ']

['Ukungabandakanyi lonke ulwazi olungentla kungakhokelela ekulibaziseni ukuphathwa kwesikhalazo sakho.']

['Unxibelelwano']

['Nceda usithumelele i-imeyile ngayo nayiphi na imibuzo / iingcebiso.']

How is prostate cancer diagnosed?

Prostate cancer is diagnosed through a combination of tests and procedures, which may include:

1. Digital Rectal Exam (DRE): A doctor inserts a gloved, lubricated finger into the rectum to feel the prostate for any abnormalities.

2. Prostate-Specific Antigen (PSA) Test: This is a blood test that measures the level of PSA, a protein produced by the prostate gland.

Elevated PSA levels may indicate the presence of prostate cancer.

3. Transrectal Ultrasound (TRUS): A small probe is inserted into the rectum to create an image of the prostate using sound waves.

This can help identify any abnormalities in the prostate gland.

4. Biopsy: A small sample of prostate tissue is removed and examined under a microscope for the presence of cancer cells.

This is the only definitive way to diagnose prostate cancer.

5. Magnetic Resonance Imaging (MRI): An MRI scan of the prostate can help identify any abnormalities and guide the biopsy procedure.

6. Genomic Testing: Some doctors may use genomic tests to help determine the aggressiveness of the cancer and guide treatment decisions.

7. Bone Scan: A bone scan may be performed to check if the cancer has spread to the bones.

8. Computed Tomography (CT) Scan: A CT scan may be used to check if the cancer has spread to other organs or tissues.

It is important to note that not all men with elevated PSA levels or abnormal DRE results will have prostate cancer, and not all prostate cancers will cause elevated PSA levels.

Therefore, a biopsy is necessary to confirm the diagnosis.

Additionally, the decision to undergo a biopsy is made after considering the results of these tests and the individual's risk factors and preferences.

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