How to treat Prostate cancer?

['Phulaphula eli phepha']

Uyiphilisa njani umhlaza wedlala lesinyi?

Kukho iindlela ezininzi zokunyanga umhlaza wedlala lesinyi, kuxhomekeke kwinqanaba lomhlaza nendlela ohlasela ngayo, kwakunye nempilo yomguli jikelele nezinto azithandayo.

Ezinye iindlela eziqhelekileyo zonyango ziquka:

1. Ukubek' esweni ngokuzimisela: Le ndlela iquka ukubek' esweni umhlaza rhoqo ngokuxilongwa nokuvavanywa, kunokuba uqalise unyango ngoko nangoko.

Isenokuba ilungele amadoda anomngcipheko ophantsi womhlaza wedlala lesinyi.

2. Utyando: Utyando lokususwa kweprostate yinkqubo yokuhlinzwa ukuze kususwe idlala lesinyi.

Inokwenziwa ngotyando oluvulekileyo okanye nge-laparoscopy (kusetyenziswa imivumbo emincinane nezixhobo ezikhethekileyo).

3. Unyango ngemitha: Olu nyango lusebenzisa imitha enamandla kakhulu ukubulala iiseli zomhlaza.

Inokufakwa ngaphandle (kumatshini ongaphandle komzimba) okanye ngaphakathi (ngokufakwa kufutshane nesimila).

4. Unyango lweehomoni: Olu nyango lunciphisa amaqondo eehomoni zamadoda (androgens) emzimbeni, nto leyo enokucothisa okanye inqande ukukhula komhlaza wedlala lesinyi.

Ingasetyenziswa yodwa okanye idityaniswe namanye amayeza.

5. Unyango ngemichiza: Olu nyango lusebenzisa amayeza okubulala iiseli zomhlaza.

Ingasetyenziselwa umhlaza wedlala lesinyi osele ukhulile osasazeke kwezinye iindawo zomzimba.

6. Unyango lwezifo zomzimba: Olu nyango lunceda inkqubo yomzimba yokuzikhusela kumhlaza.

Ingasetyenziselwa umhlaza womhlaza webele ongaphendulanga kwezinye iindlela zonyango.

7. Unyango olujoliswe kwiiseli ezinomhlaza: Olu nyango lujoliswe kwiiseli ezithile zomhlaza okanye iiprotini ezinceda iiseli zomhlaza zikhule zize ziphile.

Ingasetyenziselwa umhlaza womhlaza webele ongaphendulanga kwezinye iindlela zonyango.

8. Ukunyangwa ngomkhenkce: Olu nyango lusebenzisa ingqele egqithisileyo ukuze iiseli zomhlaza ziqandwe zize zife.

Ingasetyenziselwa umhlaza wesinyi osele uqalile okanye umhlaza obuye wabuya emva konyango.

9. IHigh-intensity focused ultrasound (HIFU): Olu nyango lusebenzisa amaza esandi aphakamileyo ukufudumeza nokutshabalalisa iiseli zomhlaza.

Ingasetyenziselwa umhlaza wesinyi osele uqalile okanye umhlaza obuye wabuya emva konyango.

10. Ukulinda: Le ndlela iquka ukujonga umhlaza rhoqo ngokuxilonga nokuvavanya, kodwa ungaqali unyango ngaphandle kokuba kuvela iimpawu okanye utshintsho.

Isenokuba yeyona ilungele amadoda amadala anomhlaza wesinyi okhula kancinci nezinye iingxaki zempilo ezinzulu.

Kubalulekile ukuxoxa ngazo zonke iindlela zonyango neqela lezempilo ukuze lifumane eyona ndlela ingcono yokunyanga imeko nganye.

['Iimbekiselo']

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Wang Y, Chen J, Wu Z, Ding W, Gao S, Gao Y, Xu C: Mechanisms of enzalutamide resistance in castration-resistant prostate cancer and therapeutic strategies to overcome it. Br J Pharmacol. 2021, 178 (2): 239-261.

Talkar SS, Patravale VB: Gene Therapy for Prostate Cancer: A Review. Endocr Metab Immune Disord Drug Targets. 2021, 21 (3): 385-396.

Šamija I, Fröbe A: CHALLENGES IN MANIPULATING IMMUNE SYSTEM TO TREAT PROSTATE CANCER. Acta Clin Croat. 2019, 58 (Suppl 2): 76-81.

Akaza H, Hinotsu S, Usami M, Ogawa O, Kagawa S, Kitamura T, Tsukamoto T, Naito S, Hirao Y, Murai M, Yamanaka H, Namiki M: The case for androgen deprivation as primary therapy for early stage disease: results from J-CaP and CaPSURE. J Urol. 2006, 176 (6 Pt 2): S47-9.

Abraham-Miranda J, Awasthi S, Yamoah K: Immunologic disparities in prostate cancer between American men of African and European descent. Crit Rev Oncol Hematol. 2021, 164 (): 103426.

de Vrij J, Willemsen RA, Lindholm L, Hoeben RC, Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G: Adenovirus-derived vectors for prostate cancer gene therapy. Hum Gene Ther. 2010, 21 (7): 795-805.

Lee E, Ha S, Logan SK: Divergent Androgen Receptor and Beta-Catenin Signaling in Prostate Cancer Cells. PLoS One. 2015, 10 (10): e0141589.

['Ukuzikhusela: unyango']

['Le webhsayithi yenzelwe ukufundisa nokunika inkcazelo kuphela yaye ayibonisi ukuba inikela amacebiso ezonyango okanye iinkonzo zobungcali.']

['Inkcazelo enikelweyo ayifanele isetyenziselwe ukuxilonga okanye ukunyanga ingxaki yempilo okanye isifo, yaye abo bafuna icebiso lonyango lobuqu bafanele babonane nogqirha onelayisensi.']

['Nceda uqaphele ukuba inethiwekhi ye-neural eyenza iimpendulo kwimibuzo, ayichanekanga xa kufikwa kumxholo wenani. Umzekelo, inani labantu abafunyaniswe benesifo esithile.']

['Soloko ucela icebiso kugqirha wakho okanye komnye umboneleli wezempilo ofanelekileyo malunga nemeko yakho yezonyango. Ungaze ungayihoyi ingcebiso yezonyango okanye ulibazise ukufuna ngenxa yento oyifunde kule webhusayithi. Ukuba ucinga ukuba unengxaki yezonyango, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko. Akukho buhlobo bukagqirha nomguli obudalwa yile webhusayithi okanye ukusetyenziswa kwayo. I-BioMedLib okanye abasebenzi bayo, okanye nabani na onegalelo kule webhusayithi, abenzi zimelo, ngokucacileyo okanye ngokungangqalanga, ngokubhekisele kulwazi olunikezwe apha okanye ekusetyenzisweni kwalo.']

['Ukuzikhulula: ilungelo lokushicilela']

['Umthetho we-Digital Millennium Copyright ka-1998, 17 U.S.C. § 512 (i-DMCA) ubonelela ngeendlela zokubhena kubanini bamalungelo obunini abakholelwa ukuba izinto ezibonakala kwi-Intanethi ziphula amalungelo abo phantsi komthetho welungelo lokushicilela wase-US. ']

['Ukuba ukholelwa ukuba kukho umxholo okanye izinto ezenziwe zafumaneka kwi-website yethu okanye iinkonzo eziphula ilungelo lakho lokushicilela, wena (okanye iarhente yakho) ungathumela isaziso esicela ukuba umxholo okanye izinto zisuswe, okanye ukufikelela kuzo kuvalwe. ']

['Izaziso kufuneka zithunyelwe ngokubhaliweyo nge-imeyile (jonga kwicandelo elithi "Qhagamshelana" ukuze ufumane idilesi ye-imeyile).']

['I-DMCA ifuna ukuba isaziso sakho sokutyholwa ngokophula ilungelo lokushicilela siquke ezi nkcukacha zilandelayo: (1) inkcazelo yomsebenzi onelungelo lokushicilela ongundaba-mlonyeni wokutyholwa ngokophula; (2) inkcazelo yomxholo otyholwa ngokophula kunye nolwazi olwaneleyo ukusivumela ukuba sifumane umxholo; (3) iinkcukacha zokuqhagamshelana nawe, kuquka idilesi yakho, inombolo yomnxeba nedilesi ye-imeyile; (4) ingxelo yakho yokuba unokholo olulungileyo lokuba umxholo ngendlela ekhalazwa ngayo awugunyaziswanga ngumnini welungelo lokushicilela, okanye iarhente yakhe, okanye ngokusebenza kwawo nawuphi na umthetho; ']

['(5) ingxelo yakho, esayinwe phantsi kwesohlwayo sobuxoki, yokuba ulwazi olukwisibhengezo luchanekile kwaye unegunya lokunyanzelisa amalungelo okushicilela ekuthiwa aphulwe;']

['kwaye (6) utyikityo lomzimba okanye lwe-elektroniki lomnini welungelo lokushicilela okanye lomntu ogunyazisiweyo ukuba enze egameni lomnini welungelo lokushicilela. ']

['Ukungabandakanyi lonke ulwazi olungentla kungakhokelela ekulibaziseni ukuphathwa kwesikhalazo sakho.']

['Unxibelelwano']

['Nceda usithumelele i-imeyile ngayo nayiphi na imibuzo / iingcebiso.']

How to treat prostate cancer?

There are several treatment options available for prostate cancer, depending on the stage and aggressiveness of the cancer, as well as the patient's overall health and personal preferences.

Some common treatments include:

1. Active surveillance: This approach involves closely monitoring the cancer with regular checkups and tests, rather than immediately starting treatment.

It may be suitable for men with low-risk prostate cancer.

2. Surgery: A prostatectomy is a surgical procedure to remove the prostate gland.

It can be done through open surgery or laparoscopically (using small incisions and specialized tools).

3. Radiation therapy: This treatment uses high-energy radiation to kill cancer cells.

It can be delivered externally (from a machine outside the body) or internally (through implants placed near the tumor).

4. Hormone therapy: This treatment reduces the levels of male hormones (androgens) in the body, which can slow or stop the growth of prostate cancer.

It can be used alone or in combination with other treatments.

5. Chemotherapy: This treatment uses drugs to kill cancer cells.

It may be used for advanced prostate cancer that has spread to other parts of the body.

6. Immunotherapy: This treatment helps the immune system fight cancer.

It may be used for advanced prostate cancer that has not responded to other treatments.

7. Targeted therapy: This treatment targets specific genes or proteins that help cancer cells grow and survive.

It may be used for advanced prostate cancer that has not responded to other treatments.

8. Cryotherapy: This treatment uses extreme cold to freeze and kill cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

9. High-intensity focused ultrasound (HIFU): This treatment uses high-frequency sound waves to heat and destroy cancer cells.

It may be used for early-stage prostate cancer or for cancer that has come back after other treatments.

10. Watchful waiting: This approach involves closely monitoring the cancer with regular checkups and tests, but not starting treatment unless symptoms appear or change.

It may be suitable for older men with slow-growing prostate cancer and other serious health conditions.

It is important to discuss all treatment options with a healthcare team to determine the best course of action for each individual case.

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