What are the risk factors for Alzheimer?

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阿尔茨海默氏症的危险因素是什么?

阿尔茨海默病有几个风险因素,包括:

1. 年龄: 随着年龄的增长, 患阿尔茨海默病的风险会增加, 大多数人会在 65 岁后被诊断出来 ⁇

2. 遗传学:有阿尔茨海默病的家族史或携带某些基因,如APOE-e4基因,可以增加患这种疾病的风险.

3. 头部受伤: 头部严重创伤或多次脑震荡可能会增加阿尔茨海默病的风险.

4. 心血管健康: 影响心脏和血管的疾病,如高血压,高胆固醇,糖尿病和肥胖,可能会增加阿尔茨海默病的风险.

5. 生活方式因素: 吸烟,过度饮酒和缺乏体育锻炼可能会增加阿尔茨海默病的风险.

6. 认知不活跃:缺乏心理刺激和低教育水平可能会增加阿尔茨海默病的风险.

7. 睡眠障碍:睡眠障碍,如睡眠呼吸暂停,可能会增加阿尔茨海默病的风险.

8. 心理因素: 抑郁,压力和社会孤立可能会增加阿尔茨海默病的风险.

值得注意的是,有一个或多个风险因素并不一定意味着一个人会患上阿尔茨海默病,一些没有已知风险因素的人仍然可能会患上这种疾病.

然而,了解这些风险因素可以帮助个人采取措施来减少风险并促进大脑健康.

参考资料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Borenstein AR, Copenhaver CI, Mortimer JA: Early-life risk factors for Alzheimer disease. Alzheimer Dis Assoc Disord. , 20 (1): 63-72.

Pansari K, Gupta A, Thomas P: Alzheimer's disease and vascular factors: facts and theories. Int J Clin Pract. 2002, 56 (3): 197-203.

Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H: Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med. 2002, 137 (3): 149-55.

Skoog I, Kalaria RN, Breteler MM: Vascular factors and Alzheimer disease. Alzheimer Dis Assoc Disord. , 13 Suppl 3 (): S106-14.

Bidzan L: [Initial symptoms and risk factors in Alzheimer's dementia]. Psychiatr Pol. , 28 (2): 207-19.

Gorelick PB: Risk factors for vascular dementia and Alzheimer disease. Stroke. 2004, 35 (11 Suppl 1): 2620-2.

Kummer BR, Diaz I, Wu X, Aaroe AE, Chen ML, Iadecola C, Kamel H, Navi BB: Associations between cerebrovascular risk factors and parkinson disease. Ann Neurol. 2019, 86 (4): 572-581.

Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R: Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology. 2005, 65 (4): 545-51.

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What are the risk factors for alzheimer?

There are several risk factors for Alzheimer's disease, including:

1. Age: The risk of developing Alzheimer's disease increases with age, with most people being diagnosed after the age of 65.

2. Genetics: Having a family history of Alzheimer's disease or carrying certain genes, such as the APOE-e4 gene, can increase the risk of developing the disease.

3. Head injury: A history of severe head trauma or multiple concussions may increase the risk of Alzheimer's disease.

4. Cardiovascular health: Conditions that affect the heart and blood vessels, such as high blood pressure, high cholesterol, diabetes, and obesity, may increase the risk of Alzheimer's disease.

5. Lifestyle factors: Smoking, excessive alcohol consumption, and lack of physical exercise may increase the risk of Alzheimer's disease.

6. Cognitive inactivity: A lack of mental stimulation and low levels of education may increase the risk of Alzheimer's disease.

7. Sleep disorders: Sleep disorders, such as sleep apnea, may increase the risk of Alzheimer's disease.

8. Psychological factors: Depression, stress, and social isolation may increase the risk of Alzheimer's disease.

It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop Alzheimer's disease, and some people with no known risk factors may still develop the disease.

However, understanding these risk factors can help individuals take steps to reduce their risk and promote brain health.

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