What is pathophysiology of Heart attack?

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心脏病发作的病理生理是什么?

心脏病发作的病理生理学,也被称为心肌梗塞,涉及到心肌的一部分血流的中断,导致心脏细胞死亡.

这通常是由于冠状动脉被血凝块阻塞而发生的,这通常是动脉硬化的结果,一种在动脉中积聚斑块的疾病.

斑块由胆固醇,脂肪物质,细胞废物,和纤维素组成.

当斑块破裂时,它可能会导致血栓形成,这可能会堵塞动脉,防止富含氧气的血液到达心肌.

这种氧气缺乏会导致心肌细胞死亡,导致心脏病发作.

损伤的程度取决于被堵塞的动脉供应的区域的大小和攻击和治疗之间的时间.

心脏病发作的症状可能包括胸部疼痛或不适,呼吸困难,恶心,头,胳膊,,下巴或背部疼痛.

心脏病发作的治疗通常包括尽快恢复心肌的血流,无论是通过药物或手术,如血管整形和支架或冠状动脉旁路手术.

值得注意的是,心脏病发作的病理生理是复杂的,涉及多种因素,包括遗传,生活方式和环境因素.

心脏病发作的危险因素包括高血压,高胆固醇,吸烟,糖尿病,肥胖,缺乏身体活动,以及家庭心脏病史.

控制这些风险因素可以帮助减少心脏病发作的可能性.

参考资料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Scott J: Pathophysiology and biochemistry of cardiovascular disease. Curr Opin Genet Dev. 2004, 14 (3): 271-9.

Liu Chung Ming C, Sesperez K, Ben-Sefer E, Arpon D, McGrath K, McClements L, Gentile C: Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells. 2021, 10 (4): .

Hansen J, Victor RG: Direct measurement of sympathetic activity: new insights into disordered blood pressure regulation in chronic renal failure. Curr Opin Nephrol Hypertens. 1994, 3 (6): 636-43.

LaMacchia JC, Roth MB: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2015, 309 (2): C92-6.

Tham YK, Bernardo BC, Ooi JY, Weeks KL, McMullen JR: Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets. Arch Toxicol. 2015, 89 (9): 1401-38.

Lonn E: The clinical relevance of pharmacological blood pressure lowering mechanisms. Can J Cardiol. 2004, 20 Suppl B (): 83B-88B.

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What is pathophysiology of heart attack?

The pathophysiology of a heart attack, also known as myocardial infarction, involves the disruption of blood flow to a part of the heart muscle, leading to the death of heart cells.

This typically occurs due to the obstruction of a coronary artery by a blood clot, which is often the result of atherosclerosis, a condition where plaque builds up in the arteries.

The plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin.

When a plaque ruptures, it can cause a blood clot to form, which can block the artery and prevent oxygen-rich blood from reaching the heart muscle.

This lack of oxygen causes the heart muscle cells to die, leading to a heart attack.

The extent of the damage depends on the size of the area supplied by the blocked artery and the time between the attack and treatment.

Symptoms of a heart attack can include chest pain or discomfort, shortness of breath, nausea, lightheadedness, and pain in the arms, neck, jaw, or back.

Treatment for a heart attack usually involves restoring blood flow to the heart muscle as quickly as possible, either through medication or procedures such as angioplasty and stenting or coronary artery bypass surgery.

It is important to note that the pathophysiology of a heart attack is complex and involves multiple factors, including genetic, lifestyle, and environmental factors.

Risk factors for heart attack include high blood pressure, high cholesterol, smoking, diabetes, obesity, lack of physical activity, and a family history of heart disease.

Managing these risk factors can help reduce the likelihood of experiencing a heart attack.

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