How is Prostate cancer diagnosed?

听这个页面 ⁇

前列腺癌是怎么诊断的?

前列腺癌是通过一系列测试和程序来诊断的,其中可能包括:

1. 数字直肠检查 (DRE): 医生将戴着手套的,润滑的手指插入直肠, 感觉前列腺的任何异常.

2. 前列腺特异性抗原 (PSA) 测试:这是测量前列腺产生的蛋白质PSA水平的血液测试.

高水平的PSA可能表明前列腺癌的存在.

3. 经直肠超声波(TRUS):一个小探头被插入直肠以使用声波创建前列腺的图像.

这可以帮助识别前列腺的任何异常.

4. 活检:取出前列腺组织的一小部分样本,并在显微镜下检查是否存在癌细胞.

这是诊断前列腺癌的唯一确切方法.

5. 磁共振成像 (MRI): 前列腺的磁共振成像可以帮助识别任何异常并指导活检程序.

6. 基因组测试:一些医生可能会使用基因组测试来帮助确定癌症的侵略性并指导治疗决定.

7. 骨头扫描:可以进行骨头扫描以检查癌症是否已经扩散到骨头.

8. 计算机断层扫描:可以使用计算机断层扫描来检查癌症是否已扩散到其他器官或组织.

值得注意的是,并非所有患有PSA水平升高或DRE结果异常的男性都会患上前列腺癌,而且并非所有前列腺癌都会导致PSA水平升高.

因此,需要进行活检来确认诊断.

此外,在考虑这些测试结果以及个人的风险因素和偏好后, 决定进行活检.

参考资料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Saldova R, Fan Y, Fitzpatrick JM, Watson RW, Rudd PM: Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia. Glycobiology. 2011, 21 (2): 195-205.

Marenco J, Kasivisvanathan V, Emberton M: New standards in prostate biopsy. Arch Esp Urol. 2019, 72 (2): 142-149.

Moradi M, Mousavi P, Abolmaesumi P: Computer-aided diagnosis of prostate cancer with emphasis on ultrasound-based approaches: a review. Ultrasound Med Biol. 2007, 33 (7): 1010-28.

Cuperlovic-Culf M, Belacel N, Davey M, Ouellette RJ: Multi-gene biomarker panel for reference free prostate cancer diagnosis: determination and independent validation. Biomarkers. 2010, 15 (8): 693-706.

McGrath SE, Michael A, Morgan R, Pandha H: EN2: a novel prostate cancer biomarker. Biomark Med. 2013, 7 (6): 893-901.

An Y, Chang W, Wang W, Wu H, Pu K, Wu A, Qin Z, Tao Y, Yue Z, Wang P, Wang Z: A novel tetrapeptide fluorescence sensor for early diagnosis of prostate cancer based on imaging Zn2+ in healthy versus cancerous cells. J Adv Res. 2020, 24 (): 363-370.

[Consensus of Chinese experts on the application of molecular imaging targeting prostate specific membrane antigen in prostate cancer patients]. Zhonghua Wai Ke Za Zhi. 2018, 56 (2): 91-94.

Zhong WD, He HC, Bi XC, Ou RB, Jiang SA, Liu LS: cDNA macroarray for analysis of gene expression profiles in prostate cancer. Chin Med J (Engl). 2006, 119 (7): 570-3.

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How is prostate cancer diagnosed?

Prostate cancer is diagnosed through a combination of tests and procedures, which may include:

1. Digital Rectal Exam (DRE): A doctor inserts a gloved, lubricated finger into the rectum to feel the prostate for any abnormalities.

2. Prostate-Specific Antigen (PSA) Test: This is a blood test that measures the level of PSA, a protein produced by the prostate gland.

Elevated PSA levels may indicate the presence of prostate cancer.

3. Transrectal Ultrasound (TRUS): A small probe is inserted into the rectum to create an image of the prostate using sound waves.

This can help identify any abnormalities in the prostate gland.

4. Biopsy: A small sample of prostate tissue is removed and examined under a microscope for the presence of cancer cells.

This is the only definitive way to diagnose prostate cancer.

5. Magnetic Resonance Imaging (MRI): An MRI scan of the prostate can help identify any abnormalities and guide the biopsy procedure.

6. Genomic Testing: Some doctors may use genomic tests to help determine the aggressiveness of the cancer and guide treatment decisions.

7. Bone Scan: A bone scan may be performed to check if the cancer has spread to the bones.

8. Computed Tomography (CT) Scan: A CT scan may be used to check if the cancer has spread to other organs or tissues.

It is important to note that not all men with elevated PSA levels or abnormal DRE results will have prostate cancer, and not all prostate cancers will cause elevated PSA levels.

Therefore, a biopsy is necessary to confirm the diagnosis.

Additionally, the decision to undergo a biopsy is made after considering the results of these tests and the individual's risk factors and preferences.

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