What are the risk factors for Breast cancer?

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乳腺癌的风险因素是什么?

乳腺癌有几个风险因素,其中一些是可以改变的,而另一些是不能改变的.

以下是一些最常见的风险因素:

1. 年龄:乳腺癌的风险随着年龄的增长而增加,大多数病例发生在50岁以上的妇女中.

2. 家庭史:如果有近亲,例如母亲,妹妹或女儿,患有乳腺癌,您的风险会增加.

3. 基因突变:某些遗传的基因突变,如BRCA1和BRCA2, 增加患乳腺癌的风险.

4. 生殖史: 早期初潮(月经开始),晚期更年期,没有孩子或在30岁后生第一个孩子可能会增加风险.

5. 激素替代疗法:在更年期后长期使用雌激素和孕激素联合激素疗法可能会增加风险.

6. 饮酒:饮酒会增加乳腺癌的风险.

7. 肥胖:超重或肥胖会增加风险,尤其是在更年期后.

8. 体育活动:缺乏体育活动可以增加风险.

9. 辐射暴露:暴露于高剂量的辐射,特别是在童年,可以增加风险.

10. 乳房密度:乳房密度高的妇女患乳腺癌的风险更高.

11. 月经史:在12岁之前开始月经或晚期更年期(55岁后)的妇女的风险略高.

12. 母乳喂养:从未母乳喂养过的妇女患乳腺癌的风险略高 ⁇

值得注意的是,有一个或多个风险因素并不意味着一个人肯定会患乳腺癌,而没有任何风险因素并不能保证一个人不会患乳腺癌.

然而,了解这些风险因素可以帮助个人就他们的健康做出明智的决定,并可能减少他们的风险.

参考资料

PubMed/Medline https://www.nlm.nih.gov/databases/download/pubmed_medline.html

RefinedWeb https://arxiv.org/abs/2306.01116

Wung SF, Hepworth JT, Sparenga D, Merkle CJ: Cardiovascular Disease Risk and Breast Cancer Outcomes: A Pilot Study. Oncol Nurs Forum. 2015, 42 (5): E330-8.

Frankl G: Risk factors in breast cancer: are they important, are they the same in pre- and post-menopausal breast cancer patients? Oncology. 1980, 37 (1): 41-5.

Ho PJ, Lau HSH, Ho WK, Wong FY, Yang Q, Tan KW, Tan MH, Chay WY, Chia KS, Hartman M, Li J: Incidence of breast cancer attributable to breast density, modifiable and non-modifiable breast cancer risk factors in Singapore. Sci Rep. 2020, 10 (1): 503.

Barnard ME, Boeke CE, Tamimi RM: Established breast cancer risk factors and risk of intrinsic tumor subtypes. Biochim Biophys Acta. 2015, 1856 (1): 73-85.

Hines LM, Risendal B, Slattery ML, Baumgartner KB, Giuliano AR, Sweeney C, Rollison DE, Byers T: Comparative analysis of breast cancer risk factors among Hispanic and non-Hispanic white women. Cancer. 2010, 116 (13): 3215-23.

Rosner B, Glynn RJ, Eliassen AH, Hankinson SE, Tamimi RM, Chen WY, Holmes MD, Mu Y, Peng C, Colditz GA, Willett WC, Tworoger SS: A Multi-State Survival Model for Time to Breast Cancer Mortality among a Cohort of Initially Disease-Free Women. Cancer Epidemiol Biomarkers Prev. 2022, 31 (8): 1582-1592.

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What are the risk factors for breast cancer?

There are several risk factors for breast cancer, some of which are modifiable and others that are not.

Here are some of the most common risk factors:

1. Age: The risk of developing breast cancer increases with age, with most cases occurring in women over the age of 50.

2. Family history: Having a close relative, such as a mother, sister, or daughter, with breast cancer increases your risk.

3. Genetic mutations: Certain inherited gene mutations, such as BRCA1 and BRCA2, increase the risk of developing breast cancer.

4. Reproductive history: Early menarche (start of menstruation), late menopause, and having no children or having the first child after age 30 can increase the risk.

5. Hormone replacement therapy: Long-term use of combined estrogen and progesterone hormone therapy after menopause can increase the risk.

6. Alcohol consumption: Drinking alcohol increases the risk of breast cancer.

7. Obesity: Being overweight or obese increases the risk, especially after menopause.

8. Physical activity: Lack of physical activity can increase the risk.

9. Radiation exposure: Exposure to high doses of radiation, particularly during childhood, can increase the risk.

10. Breast density: Women with dense breasts have a higher risk of developing breast cancer.

11. Menstrual history: Women who started menstruating early (before age 12) or went through menopause late (after age 55) have a slightly higher risk.

12. Breastfeeding: Women who have never breastfed have a slightly higher risk of developing breast cancer.

It is important to note that having one or more risk factors does not mean that a person will definitely develop breast cancer, and not having any risk factors does not guarantee that a person will not develop breast cancer.

However, understanding these risk factors can help individuals make informed decisions about their health and potentially reduce their risk.

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